A Case of Rapidly Growing Ovarian Squamous Cell Carcinoma Successfully Controlled by Weekly Paclitaxel–Carboplatin Administration

Coexistence Of Squamous Cell CarcinomaWith Dermoid Cyst Of Ovary:A Case Report

“…Stages 1C and above have been targeted with a variety of adjuvant regimens with variable outcomes. Relatively poor disease control has been noted with the conventional regimens to treat epithelial ovarian cancers, i.e cisplatin, vincristine, mitomycin C, and bleomycin (POMB) 11 . On the other hand remarkable responses have been achieved with paclitaxel based regimens in some cases 11 .…”

“…Relatively poor disease control has been noted with the conventional regimens to treat epithelial ovarian cancers, i.e cisplatin, vincristine, mitomycin C, and bleomycin (POMB) 11 . On the other hand remarkable responses have been achieved with paclitaxel based regimens in some cases 11 . Radiotherapy has also been used with the rationale of squamous cell carcinoma being a radiosensitive tumour; and has brought forth variable results for cancers within antecedent dermoids 1 .…”

Squamous Lesions of the Ovary

“…Young et al 10 have identified epidermoid cysts, some in concert with small Walthard rests, but in the absence of any other teratomatous features. Other case reports and small series [11][12][13][14][15][16][17][18][19] have identified de novo squamous cell carcinoma of the ovary, some associated with endometriosis. By all accounts, these entities are exceedingly rare, and questions remain about their histogenesis.…”

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19] Neither primary squamous cell carcinoma nor squamous cell carcinoma associated with dermoid cysts appears to be associated with significant ascites, in contradistinction to a number of other aggressive gynecologic neoplasms. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Other symptoms may relate to the invasion of the tumor into neighboring structures (eg, the urinary system and other gynecologic organs) and to distant sites (eg, liver). [11][12][13][14][15][16] In their case series, Pins et al 9 noted that squamous cell carcinoma (arising in association with a dermoid, with endometriosis or de novo endometriosis) usually presents at 52 years; it would seem, therefore, that nonmetastatic squamous cell carcinoma of the ovary is a disease of perimenopausal women, again in contradistinction to a number of other aggressive ovarian neoplasms.…”

“…[11][12][13][14][15][16] In their case series, Pins et al 9 noted that squamous cell carcinoma (arising in association with a dermoid, with endometriosis or de novo endometriosis) usually presents at 52 years; it would seem, therefore, that nonmetastatic squamous cell carcinoma of the ovary is a disease of perimenopausal women, again in contradistinction to a number of other aggressive ovarian neoplasms. A review of reported cases, [6][7][8][9][10][11][12][13][14][15][16][17][18][19] furthermore, suggests that most cases of primary squamous cell carcinoma of the ovary present at advanced stages.…”