A case of recurrent IgG4-related disease successfully treated with belimumab after remission of systemic lupus erythematosus

Katayama, Yu; Katsuyama, Takayuki; Shidahara, Kenta; Nawachi, Shoichi; Asano, Yosuke; Ohashi, Keiji; Miyawaki, Yoshia; Katsuyama, Eri; Narazaki, Mariko; Matsumoto, Yoshinori; Sada, Ken-Ei; Wada, Jun

doi:10.1093/rheumatology/keac284

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…This outcome may offer new perspectives on the management of IgG4‐RD. [ 65 ] In addition, a distinct inquiry demonstrated dual occurrences of IgG4 disease in conjunction with systemic rheumatic disorders, along with a concise evaluation of the current body of literature, suggesting a plausible common pathology among these ailments. In the first case, IgG4‐RD was found in people who also had SLE.…”

Section: Igg4 In Slementioning

confidence: 99%

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

Liu,

Wang,

et al. 2024

J Biochem & Molecular Tox

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Immunoglobulin (Ig) G4 has a distinctive nature, and its involvement in autoimmune disorders is a subject of ongoing debate and uncertainty. A growing body of evidence indicates that IgG4 may play a pathogenic role in the development of systemic lupus erythematosus (SLE). The IgG4 autoantibodies have the capability to bind autoantigens in a competitive manner with other Ig classes, thereby forming immune complexes (ICs) that are noninflammatory in nature. This is due to the low affinity of IgG4 for both the Fc receptors and the C1 complement molecule, which results in a diminished inflammatory response in individuals with SLE. The present study aims to elucidate the significance of IgG4 in SLE. The present discourse pertains to the nascent and suggested modalities through which IgG4 might participate in the pathogenesis of SLE and the potential ramifications for therapeutic interventions in SLE.

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Section: Igg4 In Slementioning

confidence: 99%