A case of relapsing polychondritis preceded by inner ear involvement

Kumakiri, Kenichi; Sakamoto, Taiko; Karahashi, Taro; Mineta, Hiroyuki; Takebayashi, Satoru

doi:10.1016/j.anl.2004.09.012

Cited by 31 publications

(16 citation statements)

References 10 publications

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“…The role of cell-mediated immune response in the pathophysiology of RP is supported by several data. Histopathological examination of affected cartilages revealed inflammatory infiltrate composed by various proportions of T-lymphocytes, mainly CD4 T-cells, macrophages, plasma cells, and immune deposits, restricted to perichondrium at an early stage and, later, spreading to cartilage [ 23 , 24 ]. Chemokines consistent with Th-1 profile, namely, interferon, interleukin (IL)-2, and IL-12, are released during this inflammatory process [ 25 ].…”

Section: Pathogenesismentioning

confidence: 99%

Relapsing Polychondritis: An Updated Review

et al. 2018

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Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. In this review article we provide a comprehensive look into clinical presentation, laboratory and instrumental investigations, diagnostic criteria, and therapeutic options.

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Section: Pathogenesismentioning

confidence: 99%

Relapsing Polychondritis: An Updated Review

et al. 2018

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“…Vestibular dysfunction is rare and documented unilaterally or bilaterally in 6–13% of patients, usually in combination with cochlear involvement [ 113 , 114 ]. Vestibular symptoms and sensorineural involvement may be due to the result of vestibular structure inflammation associated with chondritis, destruction of the Eustachian tube, and endolymphatic hydrops or due to the vasculitic process in the vestibular or cochlear branch of the internal auditory artery [ 112 , 115 ].…”

Section: Audiovestibular Pathology Associated With Systemic Autoimmentioning

confidence: 99%

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Girasoli

Cazzador

Padoan

et al. 2018

Journal of Immunology Research

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The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. The association of vertigo and autoimmune diseases has been largely documented, suggesting that autoimmune disorders could be overrepresented in patients with vertigo in comparison to the general population. The aim of this review is to present the recent literature findings in the field of autoimmune-mediated diseases with cochleovestibular involvement, focusing on the clinical presentation, diagnosis, and treatment of immune-mediated inner ear diseases including autoimmune inner ear disease (AIED), Meniere's disease, and bilateral vestibulopathy, as well as of systemic autoimmune diseases with audiovestibular disorders, namely, Behçet's disease, Cogan's syndrome, sarcoidosis, autoimmune thyroid disease, Vogt-Koyanagi-Harada syndrome, relapsing polychondritis, systemic lupus erythematosus, antiphospholipid syndrome, IgG4-related disease, and ANCA-associated vasculitides.

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“…SNHL is often permanent, presenting a variable pattern from sudden, or rapidly/ gradually progressive. In particular, it is uncommon that profound hearing loss is the first manifestation of the disease [3]. The pathogenesis of SNHL is still unclear: the presence of both circulating antilabyrinthine antibodies and vasculitis of the labyrinthine artery and its branches have been shown, supporting the hypothesis of an immune-mediated SNHL [4].…”

Section: Introductionmentioning

confidence: 99%

Deterioration of hearing in a cochlear implantee with relapsing polychondritis

Mancini

Attanasio

Viccaro

et al. 2011

Acta Oto-Laryngologica

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We report on a rare case of cochlear implantation in a patient affected by relapsing polychondritis (RP), which over time induced cochlear fibrosis/ossification and deterioration of previously excellent hearing performance. The clinical course was determined by CT scan, electrophysiology, and speech perception data. We conclude that RP is a severe autoimmune connective disorder that can cause profound sensorineural hearing loss. Cochlear implantation in these patients can provide excellent performance. Continuation of therapy may improve prognosis, but relapses involving inner ear structures can determine fibrosis/ossification of the modiolus and interfere with cochlear implant use.

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A case of relapsing polychondritis preceded by inner ear involvement

Cited by 31 publications

References 10 publications

Relapsing Polychondritis: An Updated Review

Relapsing Polychondritis: An Updated Review

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Deterioration of hearing in a cochlear implantee with relapsing polychondritis

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