A case of renal cell carcinoma with metastasis to the thyroid gland and concomitant early gastric cancer

Abstract

Metastatic lesions from renal cell carcinoma are commonly recognized in the lung and bone, however, thyroid metastasis has rarely been reported in the literature. We present herein a case of a man with lung and thyroid metastatic tumors from renal cell carcinoma. Although making a preoperative diagnosis of thyroid metastasis is difficult because there is no established diagnostic criteria, we were able to identify this thyroid lesion as a metastatic tumor from renal cell carcinoma by the pathological findings. Interestingly, hypercalcemia was recognized in this patient whose serum parathyroid hormone (PTH) level was not increased. Moreover, this patient also had early gastric cancer simultaneously, being a so-called 'double cancer'. After surgical resection of the right kidney and stomach, interferon was administered without any efficacy against the metastatic lesions of the lung and thyroid gland.

Surgical Outcome of Synchronous Second Primary Cancer in Patients with Gastric Cancer

“…The incidence of gastric cancer with renal cell carcinoma is quite low 22,23. Moreover, synchronous surgery of gastric cancer and renal cell carcinoma is extremely rare 6,7.…”

Metastasis of distal esophageal carcinoma to the thyroid with presentation simulating primary thyroid carcinoma: a case report and review of the literature

“…The role of radiation therapy is still controversial because thyroid metastases are mainly revealed as highly anaplastic carcinomas and are usually radiation-resistant, and are often rapidly fatal. Furthermore, until recently there has been no clear consensus on the election of surgical means for metastatic thyroid cancers [5,7,24]. Sadly, thyroidectomy had no remarkably beneficial effects on the outcome of our patient.…”

Thyroid Metastasis from Gastric Carcinoma: Report of a Case

“…[6][7][8] The T 3 and TSH levels were at the lower end of the normal range in our patient, in accordance with previous case reports. 2,9 There is no consensus regarding the role of surgery for metastatic thyroid cancers. Some authors support thyroidectomy for slowly growing tumors, whereas others argue that thyroidectomy has no effect on survival for rapidly growing tumors.…”