A Case of Renal Inflammatory Pseudotumor Leading to Nephrectomy

Abstract

Inflammatory pseudotumor (IPT) of the kidney is a rare benign disorder with unknown etiology. In IPT patients, some nonspecific symptoms might present, such as fever, hematuria, and back pain. As it can appear on computed tomography and magnetic resonance imaging as a hypovascular mass with surrounding fat stranding, IPT can be misdiagnosed as a primary tumor. Since the clinical symptoms, radiographic features, and preoperative findings can be inconsistent, it is imperative to confirm IPT based on histopathological assessment. In the present study, we describe a case of renal IPT in a 13-year-old girl. The patient was treated with nephrectomy of the right kidney since the preoperative diagnosis was renal carcinoma. Pathological examination revealed an IPT. This article emphasizes the importance of preoperative definitive diagnosis in avoiding unnecessary nephrectomy.

Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl

“…The IMT, however, can be triggered by a variety of illnesses, including viral or autoimmune disorders. Some pathogenic organisms, like Actinomyces, Pseudomonas species, and mycoplasmal infections, have been related to IMT of the kidneys based on the scarcely published data on this condition [ 2 ]. In some cases of IMT, a positive test for Epstein-Barr virus latent membrane protein has been identified, increasing the likelihood that this virus is the causal culprit.…”

“…The diagnosis of the IMT is challenging, and imaging using CT and MRI of the abdomen and pelvis with or without contrast alone is insufficient for the precise diagnosis [ 2 ]. The radiographic findings in renal IMT are not well understood.…”

“…The various terms used are plasma cell granuloma, inflammatory pseudotumor, fibroxanthoma, and xanthogranuloma [ 1 ]. It can affect any organ/system of the body, including lungs, gastrointestinal tract (mesentery), omentum, liver, head and neck, and urogenital system, with lungs being the most common site of occurrence [ 2 , 3 ]. Renal IMT, however, is very rare, and only a limited number of cases have been reported in the medical literature [ 2 ].…”

“…It can affect any organ/system of the body, including lungs, gastrointestinal tract (mesentery), omentum, liver, head and neck, and urogenital system, with lungs being the most common site of occurrence [ 2 , 3 ]. Renal IMT, however, is very rare, and only a limited number of cases have been reported in the medical literature [ 2 ]. IMT can occur in any age group; however, it usually occurs in children and young adults [ 1 , 2 ].…”

“…Renal IMT, however, is very rare, and only a limited number of cases have been reported in the medical literature [ 2 ]. IMT can occur in any age group; however, it usually occurs in children and young adults [ 1 , 2 ].…”