A case of resistant multiple plantar warts cured with combined autologous platelet‐rich plasma injection and topical salicylic acid 30%

El‐Hamd, Mohammed Abu; Aboeldahab, Soha

doi:10.1111/jocd.14468

Cited by 3 publications

(5 citation statements)

References 8 publications

(17 reference statements)

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“…ILI of PRP in plantar warts could be efficient and safe immunotherapy; this could be clarified by the fact that PLT express a lot of TLRs 1, 2, 3, 4, 6, 7, and 9 [19] . Upon stimulation, the TLRs increase the synthesis of INF and several cytokines as IL-6, IL-8 and TNF-α, which after that trigger several immune cells with subsequent increase in the inflammatory process [20] .…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the use of PRP therapy in warts, Abu El-Hamd and Aboeldahab [20] assessed the potential efficiency of PRP in the management of multiple resistant plane warts. CR was noticed in 20% after the 1 st session and 100% after the 2 nd session.…”

Section: Discussionmentioning

confidence: 99%

“…Abu El-Hamd and Aboeldahab [20] recorded that there was a CR for recalcitrant plantar warts of an immunocompetent male cases following three sessions of ILI of APRP (30 days apart), combined with topical salicylic acid 30% solution (every 12 hours). Additionally, there was no relapse following a 9-month follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study between the Efficacy of Intralesional Injection of Platelet Rich Plasma versus Topical Zink Oxide Paste 20% in the Treatment of Common Warts

2024

The Egyptian Journal of Hospital Medicine

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Background: Cutaneous warts are benign epidermal proliferations caused by human papilloma virus (HPV). Zink (Zn) has been utilized in different preparations in the treatment of common warts (CWs) as oral Zn sulphate, intralesional 2% Zn sulphate, topical application of 10%, and 5% Zn sulfate (ZnSO4) with different success rates. The platelet rich plasma (PRP) is being utilized in numerous and various dermatological indications as in alopecia, tissue regeneration, wound healing, scar revision, and skin rejuvenation. Objective: To compare the efficacy of intralesional injection (ILI) of platelet rich plasma versus 20% topical Zn oxide (ZnO) paste in treatment of common viral warts. Patients and Methods: This study was a prospective randomized controlled trial (RCT) that was conducted over one year and included 100 patients with clinically evident, numerous CWs and were divided into two groups, group A comprised 50 patients treated with ILI of autologous PRP (APRP) and group B included 50 patients managed with 20% ZnO paste. The outcomes were assessed one month, two months and after six months from the last injection. Results: After one month of treatment, Group A had a notably better outcome in terms of excellent responses to treatment. After six months of treatment there was a significant difference in the rate of complete cures where group A showed statistically significant higher rates of complete cure. The mean percentage of improvement for Group A was statistically significantly higher than in Group B (p value<0.001). Conclusion: PRP was superior in efficacy to topically applied 20% ZnO paste in treatment of common viral warts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparative Study between the Efficacy of Intralesional Injection of Platelet Rich Plasma versus Topical Zink Oxide Paste 20% in the Treatment of Common Warts

2024

The Egyptian Journal of Hospital Medicine

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“…Both groups were comparable in terms of age, duration, and number of warts. According to recent studies, treatment of plane warts is challenging and they are often difficult to clear 12,13 . There are multiple methods used for treating plane warts in published studies, so we decided to compare our treatment outcomes of plane warts with outcomes of other studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Topical Adapalene and Electrocautery in Treatment of Plane Warts

Tahir,

Hassan,

Shahzad

et al. 2023

PJMHS

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Background: Warts are lesions that grow on the human skin due to infection named human papilloma-virus (HPV) type 1, 2, and 4. More than 100 types of HPV virus have been identified now. Aim: To compare the efficacy of adapalene and electrocautery therapies in managing plane warts. Study design: Randomized Control Trial. Methodology: A total of 52 patients via non probability consecutive sampling technique with plane warts were enrolled and randomly divided into 2 equal groups. The patients of Group A were treated with 0.5% Adapalene gel (applied twice daily over the lesions for maximum 3 months or until resolution of warts) and patients in group B were treated with electro-cautery procedure fortnightly for maximum 3 months or until resolution of warts). Patients were assessed after every 2 weeks for initial 3 months and then these patients were followed monthly for another 3 months and final outcome was seen at 6 months. Data was evaluated by using SPSS version 23. Student-t test was applied with p-value than 0.05 taken as significant. Results: The mean duration of wart resolution was observed as 45.92±19.22 days in the adapalene group, while the electro-cautery procedure took 45 ± 17.81 days for wart clearance. There were no statistically significant differences in the complications between the two groups (p=0.60). Practical Implication: Although successful outcomes have been achieved in many studies by using Adapalene and electrocautery separately for treating warts but none of the published research compares these two treatment modalities (Adapalene vs electrocautery) for treatment of plane warts as per our knowledge. Therefore to fill this gap, this study was designed to compare the efficacy of adapalene and electrocautery therapies. Conclusion: It was concluded that Both Adapalene and electrocautery are effective in treatment of plane warts and there are no statistically significant differences in the complications/side effects of these two treatment modalities. Keywords: Adapalene Gel 0.1%, Electrocautery, Plane Warts, Clinical Outcomes and Effectiveness.

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“…Warts (verrucae) are very common benign skin tumors affecting both sexes and all ages 1 . Plantar warts, affecting the plantar surfaces of the feet, represent about 30% of all cutaneous warts 2 with an annual incidence of about 14%. They are commonly associated with human papilloma virus (HPV) types 1, 2, 4, 10, 27, and 57 3 .…”

Section: Introductionmentioning

confidence: 99%

Intralesional full‐concentration (25 mg/ml) methotrexate in the treatment of plantar warts: A pilot study

Zoheir

Almohsen

Amer

et al. 2022

Dermatologic Therapy

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Plantar warts continue to represent a therapeutic challenge due to treatment resistance and high recurrence rates. Intralesional methotrexate, a cytotoxic chemotherapeutic agent with in-vitro anti-viral properties has been used for many dermatological indications. Two previous studies evaluated intralesional injection of diluted methotrexate (in 0.5, 1, and 2 mg/ml dilutions) in the treatment of warts and found it poorly effective.The concentrations used in these studies were much lower than those used for other indications. The current, open-label, prospective, pilot study aimed to evaluate the safety and efficacy of the intralesional injection of full concentration (25 mg/ml) methotrexate in the treatment of plantar warts. Twenty patients with plantar warts, 10 (50%) males, and 10 (50%) females, with mean ± SD age of 28.45 ± 8.66 years (range, 18-46 years) received biweekly sessions of intralesional methotrexate (25 mg/ml) until complete clearance or for a maximum of 6 sessions. Complete clearance of warts was achieved in 2 (10%), 6 (30%), and 7 (35%) patients after 4, 5, and 6 sessions, respectively. Another 8 (40%) patients showed partial improvement after 6 sessions. The response rate did not correlate significantly with the number of warts. Nine (45%) patients did not report any side effects. Pain and bruises were reported by 8 (40%) and 6 (30%) patients, respectively. These findings suggest that biweekly sessions of full (25 mg/ml) concentration of methotrexate are a safe and effective treatment for plantar warts. It may be considered an alternative line of treatment for resistant cases.

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A case of resistant multiple plantar warts cured with combined autologous platelet‐rich plasma injection and topical salicylic acid 30%

Cited by 3 publications

References 8 publications

Comparative Study between the Efficacy of Intralesional Injection of Platelet Rich Plasma versus Topical Zink Oxide Paste 20% in the Treatment of Common Warts

Comparative Study between the Efficacy of Intralesional Injection of Platelet Rich Plasma versus Topical Zink Oxide Paste 20% in the Treatment of Common Warts

Comparison of Topical Adapalene and Electrocautery in Treatment of Plane Warts

Intralesional full‐concentration (25 mg/ml) methotrexate in the treatment of plantar warts: A pilot study

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