A Case of Rhabdomyolysis due to Levofloxacin

Nakamae, Hirohisa; Hino, Masayuki; Yamane, Takahisa; Ohta, Kensuke; Aoyama, Yasutaka; Kumura, Takeo; Sannomiya, Y; Tatsumi, Noriyuki

doi:10.2165/00044011-200020030-00008

Cited by 10 publications

(14 citation statements)

References 5 publications

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“…in 1996 [1]. Levofloxacin-induced rhabdomyolysis was first reported in 2000 and thus far only a few cases have been reported [4–7]. Previous reports that rhabdomyolysis occurs within 6 days of initiation of levofloxacin remained true in our case also.…”

Section: Discussionsupporting

confidence: 60%

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Levofloxacin-induced rhabdomyolysis: a case report

2016

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BackgroundRhabdomyolysis secondary to quinolones is not frequent. There are scarce reports in the literature associating rhabdomyolysis to levofloxacin. We describe a case of levofloxacin-induced rhabdomyolysis.Case presentationA 52-year-old African-American man presented with muscle tightness after taking three doses of levofloxacin. He had elevated creatine kinase without acute kidney injury. His symptoms resolved after discontinuation of levofloxacin and supportive care.ConclusionsIt is fascinating that our patient has a prior history of rhabdomyolysis, likely from levofloxacin. Our case highlights the need to be mindful of this potentially life-threatening complication of levofloxacin.

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Section: Discussionsupporting

confidence: 60%

“…Management is by stopping the offending agent along with adequate hydration to prevent acute renal failure. Systemic steroids although reported to have a beneficial effect, were not used in this case due to lack of scientific evidence [7]. …”

Section: Discussionmentioning

confidence: 99%

Levofloxacin-induced rhabdomyolysis: a case report

2016

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“…This case report highlights levofloxacin as a rare cause of rhabdomyolysis. There have been several other case reports of levofloxacin causing rhabdomyolysis in nondialysis 3,4 or renal transplant recipients. 5 Some of these cases were much more severe than ours, resulting in some of the poor outcomes of rhabdomyolysis, such as acute renal failure, anuria, metabolic acidosis, fatal hyperkalemia and compartment syndromes.…”

Section: Discussionmentioning

confidence: 99%

Levofloxacin‐induced rhabdomyolysis in a hemodialysis patient

Gupta

Guron

Harris

et al. 2011

Hemodialysis International

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“…1,7 The fluoroquinolone antibiotics (e.g., ciprofloxacin) also have been reported to be associated with musculoskeletal adverse events such as tendinopathy and tendon rupture, and may increase the risk for rhabdomyolysis due to muscle toxicity. [8][9][10] The risk of statinassociated myopathy has been described as dose dependent. 2,3 Results of a placebo-controlled clinical trial of cerivastatin, for example, showed that the rate of CK elevations in patients taking cerivastatin was greater compared to other statin therapies and dependent on dosage.…”

Section: Introductionmentioning

confidence: 99%