A case of scleromyxoedema with thyroid dysfunction

Li, Lin; Jiang, Cunhuo; Lu, Yiming; Zhang, Pei

doi:10.4103/0019-5154.139925

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Thyroid gland disorders have been associated with cutaneous mucinosis with the pretibial myxedema (thyroid dermopathy) as the most common presentation, particularly in patients with Graves' disease. Thyroid dermopathy is characterized clinically by localized thickening of the skin with overlying peau d'orange appearance and histologically by mucin deposition in the reticular dermis, with almost no fibroblast proliferation . In addition, other dermatologic manifestations of both hyperthyroidism (such as thyroid acropachy, hyperhidrosis, fine smooth skin, and diffuse thinning of hair) and hypothyroidism (such as pale skin color, dry rough skin, elephantiasis‐like picture, and sparse brittle hair) do not simulate the characteristic lesions of LM.…”

Section: Thyroid Disorder and Lichen Myxedematosusmentioning

confidence: 99%

Lichen myxedematosus: diagnostic criteria, classification, and severity grading

Nofal

Amer²,

Alakad

et al. 2016

Int J Dermatology

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We propose two sets of diagnostic criteria to define the disease more precisely and to avoid confusion associated with the other classification. The first set comprises constant clinical and histopathological features that are always present in every case, and the second set includes associated features that were variably reported in some patients. LM is then subclassified according to the presence or absence of systemic manifestations into a systemic severe form (scleromyxedema) and a non-disabling, pure cutaneous form.

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Section: Thyroid Disorder and Lichen Myxedematosusmentioning

confidence: 99%

Lichen myxedematosus: diagnostic criteria, classification, and severity grading

Nofal

Amer²,

Alakad

et al. 2016

Int J Dermatology

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“…No nerve thickening was seen in our case, there was no sensory or motor loss, and slit‐skin smear was negative for acid‐fast bacilli, excluding lepromatous leprosy. Scleromyxedema was considered as a differential diagnosis of leonine facies with waxy infiltration, but absence of monoclonal proteins in serum and urine electrophoreses and absence of mucoid material and proliferating fibroblasts in dermis excluded scleromyxedema as a cause of leonine facies in our case …”

Section: Discussionmentioning

confidence: 72%

“…Scleromyxedema was considered as a differential diagnosis of leonine facies with waxy infiltration, but absence of monoclonal proteins in serum and urine electrophoreses and absence of mucoid material and proliferating fibroblasts in dermis excluded scleromyxedema as a cause of leonine facies in our case. 5 Trichoepitheliomatous infiltration has been shown to cause alopecia of the eyebrows, scalp, and body. 3 We observed loss of hair in our patient over the infiltrated area, including on the lateral aspect of the eyebrow, moustache, and beard areas.…”

Section: Discussionmentioning

confidence: 99%

Early leonine facies with alopecia in a young man

2016

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“…Rongioletti and Rebora [1] may include the absence of thyroid disease as part of the diagnosis because hypothyroidism can present with generalized myxedema and histology showing mucin deposition [3]. However, there are multiple cases of scleromyxedema and LM in addition to ours that have been diagnosed with concurrent thyroid disease [2, 4, 5]. Our patients presented with forms of papular mucinosis years after hypothyroidism had been diagnosed and sufficiently treated.…”

Section: Discussionmentioning

confidence: 85%

Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases

Shenoy

Steixner

Beltrani³

et al. 2019

Case Rep Dermatol

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Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. However, atypical cases that lack monoclonal gammopathy and that present with hypothyroidism have been reported, suggesting that these criteria may require revision. First, we report a case of a 58-year-old female with a history of Hashimoto thyroiditis and biopsy-proven scleromyxedema responsive to intravenous immunoglobulin therapy with delayed presentation of monoclonal gammopathy. Next, we report a case of a 54-year-old female with a history of hypothyroidism, Hodgkin’s lymphoma in remission after radiation and chemotherapy, and concurrent rheumatoid arthritis, with biopsy-proven LM temporarily responsive to systemic steroids. Our cases demonstrate that patients with papular mucinoses can have a multitude of concurrent and prior rheumatologic and endocrine conditions, including thyroid disease, which should not preclude a diagnosis of scleromyxedema and LM.

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A case of scleromyxoedema with thyroid dysfunction

Cited by 3 publications

References 4 publications

Lichen myxedematosus: diagnostic criteria, classification, and severity grading

Lichen myxedematosus: diagnostic criteria, classification, and severity grading

Early leonine facies with alopecia in a young man

Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases

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