A case of <scp>HER</scp>2‐positive male occult breast carcinoma with skin and lymph node metastases that exhibited complete response to trastuzumab monotherapy

Kuninaka, Kouichi; Takahashi, Ryo; Nakagawa, Yutaka; Nishimaki, Tadashi

doi:10.1002/ccr3.884

Cited by 6 publications

(9 citation statements)

References 8 publications

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“…In this review, ER and PR were positive in seven patients of which two patients were also HER-2 positive; one patient presented only progesterone receptors, two presented only HER-2 positive and two were triple-negative (3,7,9). Positive HER-2 breast cancer is seen in approximately 25-30% of cases and confers worse biological behavior (7,16). Our case was ER and PR negative, and HER-2 positive, which lead to discarding hormonal therapy.…”

Section: Discussionmentioning

confidence: 64%

“…So, the identification of receptors is key for diagnosis, and evaluation to determine the necessity of hormonal therapy (5). In this review, ER and PR were positive in seven patients of which two patients were also HER-2 positive; one patient presented only progesterone receptors, two presented only HER-2 positive and two were triple-negative (3,7,9). Positive HER-2 breast cancer is seen in approximately 25-30% of cases and confers worse biological behavior (7,16).…”

Section: Discussionmentioning

confidence: 91%

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A challenging diagnosis of occult breast cancer in men: a case report

Garnica¹,

Barco‐Castillo²,

Vanegas³

et al. 2022

AME Surg J

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We present a case of a 38-year-old male patient with a left axillary metastatic mass without evidence of the primary lesion. Needle aspiration biopsy was performed showing a HER-2 positive occult breast cancer (OBC). The patient underwent neoadjuvant chemotherapy and radical modified mastectomy followed by radiotherapy and systemic therapy. Genetic studies were negative, and the follow-up showed no relapse. OBC is defined as a mammary gland neoplasm that presents as a metastatic disease without clinical or radiological manifestation of the primary tumor. The incidence of OBC in men is unknown and is limited to case reports. A systematic review was performed including eleven case reports with twelve patients ranging from 29 to 83 years old. Estrogen and progesterone receptors were positive in seven patients of which two patients were also HER-2 positive; one patient presented only progesterone receptors, two presented only HER-2 positive and two were triple-negative. Operative management, hormonal therapy, chemotherapy, and radiotherapy were performed together or apart depending on the attending and the patient's preferences.No one reported mortality due to malignant disease. OBC is a rare pathology in men and requires a high diagnostic suspicion in patients with an axillary or thoracic metastatic disease without an evident primary neoplasm. The genetic study is necessary to determine mutations and evaluate the risk of relapse and the high risk of primarily associated neoplasm in the patient and family.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 91%

A challenging diagnosis of occult breast cancer in men: a case report

Garnica¹,

Barco‐Castillo²,

Vanegas³

et al. 2022

AME Surg J

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“…Twelve articles published from 2008 to 2020 and reporting cases of CUP of breast cancer origin were identified (27,(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) (Table I). The mean age of the patients was 59,23 years (range 29 to 83).…”

Section: Discussionmentioning

confidence: 99%

“…Three men were smokers (35,38,39) and two of them (35,38) referred a familiarity for gastric cancer: in a case the father, and in the other the mother was affected. In 12 cases reported the first presentation was an axillary mass; in one case the tumor was located on the anterior chest wall (29) while in another case, a vertebral painful lesion was diagnosed in the same moment of the axillary nodule (39). Seven men was affected by comorbidities: four of them showed dermatologic disease such as eczema, reddish skin, dermatomyositis, and erythema (27,29,(34)(35).…”

Section: Discussionmentioning

confidence: 99%

“…In 12 cases reported the first presentation was an axillary mass; in one case the tumor was located on the anterior chest wall (29) while in another case, a vertebral painful lesion was diagnosed in the same moment of the axillary nodule (39). Seven men was affected by comorbidities: four of them showed dermatologic disease such as eczema, reddish skin, dermatomyositis, and erythema (27,29,(34)(35). A patient had a benign thyroid nodule (35), one presented gynecomastia (37), and another found out a renal cystic (39).…”

Section: Discussionmentioning

confidence: 99%

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Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review

Parisi,

Gambardella,

Ruggiero

et al. 2024

Oncol Lett

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Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of CUPs. The present study describes the case of a 64-year-old man affected by a CUP of presumed mammary origin. The aim of the article and the present review was to focus on their management. To the best of our knowledge, only thirteen cases have been reported in the literature. Because no specific guidelines are available, various approaches have been applied, influencing the treatment and the prognosis of patients with CUP.

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Diagnosis, investigation, and treatment of occult breast cancer: A case report and systematic review of the literature

Trabulsi,

Almaghrabi,

Bamakhrama

et al. 2024

Current Problems in Cancer: Case Reports

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A case of HER2‐positive male occult breast carcinoma with skin and lymph node metastases that exhibited complete response to trastuzumab monotherapy

Abstract: Key Clinical MessageMetastatic male occult HER2‐positive breast cancer can be successfully treated with trastuzumab monotherapy.

Cited by 6 publications

References 8 publications

A challenging diagnosis of occult breast cancer in men: a case report

A challenging diagnosis of occult breast cancer in men: a case report

Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review

Diagnosis, investigation, and treatment of occult breast cancer: A case report and systematic review of the literature

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