A Case of Sebaceous Adenitis and Concurrent Meibomian Gland Dysfunction in a Dog

Sartori, Roberta; Peruccio, Claudio

doi:10.3390/vetsci7020037

Cited by 9 publications

(18 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hematoxylin-eosin (HE) staining of resected eyelid tissue revealed the absence of normal gland lobular and ductal structures at the dropout site, and noncontact infrared meibography (NIM) revealed Meibomian gland atrophy [33]. Another case report demonstrated that a two-year-old neutered female mongrel dog presented sebaceous adenitis and concurrent MGD [34]. This condition is also common in human patients.…”

Section: Pathogenesis Of Mgd In Humans and Other Mammalian Speciesmentioning

confidence: 99%

Meibomian Gland Dysfunction: What Have Animal Models Taught Us?

Sun

Moreno

Dang

et al. 2020

IJMS

View full text Add to dashboard Cite

Studies have estimated that currently 344 million people worldwide and 16.4 million adults in the US have some form of dry eye disease (DED). It is believed that approximately 70% of DED cases are due to some form of evaporative dry eye, for which Meibomian gland dysfunction (MGD) is the major cause. Unfortunately, currently there is no effective treatment for MGD, and solely palliative care is available. Given the importance of MGD in DED, there has been a growing interest in studying Meibomian gland development, homeostasis and pathology, and, also, in developing therapies for treating and/or preventing MGD. For such, animal models have shown to be a vital tool. Much of what is known today about the Meibomian gland and MGD was learnt from these important animal models. In particular, canine and rabbit models have been essential for studying the physiopathology and progression of DED, and the mouse model, which includes different knockout strains, has enabled the identification of specific pathways potentially involved in MGD. Herein, we provide a bibliographic review on the various animal models that have been used to study Meibomian gland development, Meibomian gland homeostasis and MGD, primarily focusing on publications between 2000 and 2020.

show abstract

Section: Pathogenesis Of Mgd In Humans and Other Mammalian Speciesmentioning

confidence: 99%

Meibomian Gland Dysfunction: What Have Animal Models Taught Us?

Sun

Moreno

Dang

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…With regard to meibography, in veterinary medicine, there is not sufficient available documentation. Rabbits have been studied in main human medicine research projects [ 29 – 31 ], while canine studies have been conducted on meibomian gland disorder (MGD) associated with keratoconjunctivitis, ocular surface disorder (OSD) and sebaceous adenitis [ 19 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical parameters obtained during tear film examination in domestic rabbits

Corsi¹,

Arteaga²,

Corsi

et al. 2022

BMC Vet Res

Self Cite

View full text Add to dashboard Cite

Background One of the contributing factors to ocular surface health is a stable precorneal tear film. Considering the increasing interest in rabbits as pets and the limited literature available on domestic rabbit tearing, the aim of this study was to establish normative data for examination of the tear film in domestic rabbits. Results The study included 75 client-owned domestic Holland Lop rabbits (150 eyes). The following examinations were performed in each eye: Schirmer tear test-1, tear osmometry, interferometry, tear meniscus height measurement and meibography (quantifying meibomian gland loss as a percentage). The resulting median (95% central range) values were 10.0 (5.0–17.3) mm/min for the Schirmer tear test-1, 345.0 (280.5–376.1) mOsm/L for tear osmolarity, grade 2 (1–4) of interferometry, 0.28 (0.20–0.47) mm for tear meniscus height and 0.0 (0.0–67.6) % meibomian gland loss. A significant association was found between tear osmolarity and age, with an estimated decrease of − 4.0 mOsm/L with each additional year of age (p < 0.001). The distributions of interferometry grades were significantly different between males and females (p < 0.001), with grade 1 and grade 2 being the most frequent in females and males, respectively. A weak negative correlation was also observed between interferometry grade and the percentage of meibomian gland loss (r = − 0.22, p = 0.006). Conclusions This is an original study that documents extensive tear film parameters in healthy Holland Lop rabbits. The results can be used as normative data for the examination of the tear film in this lagomorph breed.

show abstract

“…True MGD in horses has not been previously reported, to the authors' knowledge. However, canine MGD has only recently become an active area of research, begging the consideration that this condition may also be present in the equine population 3,4,6 …”

Section: Discussionmentioning

confidence: 99%

“…5 In dogs, MGD has been implicated as a cause of ocular surface disorders. 4,6 To the authors' knowledge, true MGD has not been officially diagnosed in horses. However, other meibomian gland disorders including meibomianitis have been identified and are established causes of evaporative dry eye and granulomatous lesions.…”

mentioning

confidence: 92%

See 1 more Smart Citation

Calcification and osseous metaplasia of the meibomian glands of a horse

Gunsalus¹,

Taylor

Croix³

2022

Veterinary Ophthalmology

View full text Add to dashboard Cite

Meibomian glands are specialized sebaceous glands in the eyelid margin that produce the lipid component of the precorneal tear film. 1,2 The lipid layer reduces tear film evaporation, impedes overflow tearing, and facilitates blinking. Loss of meibomian gland function is detrimental to corneal health. 3,4 Meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye in humans. 3 In humans with MGD, chronic inflammation can lead to calcium concretions within the meibomian glands. 5 In dogs, MGD has been implicated as a cause of ocular surface disorders. 4,6 To the authors' knowledge, true MGD has not been officially diagnosed in horses. However, other meibomian gland disorders including meibomianitis have been identified and are established causes of evaporative dry eye and granulomatous lesions. 1,2,7 There are several known causes

show abstract

A Case of Sebaceous Adenitis and Concurrent Meibomian Gland Dysfunction in a Dog

Cited by 9 publications

References 8 publications

Meibomian Gland Dysfunction: What Have Animal Models Taught Us?

Meibomian Gland Dysfunction: What Have Animal Models Taught Us?

Clinical parameters obtained during tear film examination in domestic rabbits

Calcification and osseous metaplasia of the meibomian glands of a horse

Contact Info

Product

Resources

About