A case of secondary syphilis masquerading as cutaneous lymphoma

Nethers, Kevin; Mojica, Rafael; Marks, Etan; Burger, Robin; Saeed, Sadia; Steffes, William

doi:10.1016/j.jdcr.2021.05.036

Cited by 4 publications

(11 citation statements)

References 10 publications

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“…We looked at 10 published cases of secondary syphilis that were first suspected as lymphoma (Table 1). [1][2][3][4][5][6][7][8][9][10] We found that these patients all presented with prominent nodules JEADV 2022, 36, e1027-e1029 e1028 that have minimum scales/crusts on top. Although some of these patients have systemic symptoms such as fever and malaise, majority of them spared of having B symptoms (weight loss and night sweats) that are alarming for malignancy.…”

Section: Editormentioning

confidence: 99%

Secondary syphilis resembling lymphoma‐like nodules in a 59‐year‐old woman

Sun

Yang

Huang

et al. 2022

Acad Dermatol Venereol

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Section: Editormentioning

confidence: 99%

Secondary syphilis resembling lymphoma‐like nodules in a 59‐year‐old woman

Sun

Yang

Huang

et al. 2022

Acad Dermatol Venereol

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“…Mucocutaneous lesions in syphilis present in myriad ways, at times mimicking cutaneous T-cell lymphoma or B-cell lymphoma. [31][32][33][34][35] Notably, epidermal interface changes are often present in syphilis but absent in lymphoma. 36 Syphilis lesions can present as macules, papules, bullae, papulonodules, or plaques.…”

Section: Syphilismentioning

confidence: 99%

“…Rupioid syphilis, syphilis maligna, and plasmacytoma-like pattern syphilis are rare presentations of syphilis that can show abundant plasma cells. 33,42…”

Section: Syphilismentioning

confidence: 99%

“…Mucocutaneous lesions in syphilis present in myriad ways, at times mimicking cutaneous T‐cell lymphoma or B‐cell lymphoma 31–35 . Notably, epidermal interface changes are often present in syphilis but absent in lymphoma 36 .…”

Section: Reactive B‐cell Clhmentioning

confidence: 99%

“…Observation of spirochetal organisms is key and can be performed by Steiner/Warthin–Starry stains. Rupioid syphilis, syphilis maligna, and plasmacytoma‐like pattern syphilis are rare presentations of syphilis that can show abundant plasma cells 33,42 …”

Section: Reactive B‐cell Clhmentioning

confidence: 99%

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Cutaneous reactive B‐cell lymphoid proliferations

Khalil

Donthi²,

Gru

2022

J Cutan Pathol

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Cutaneous lymphoid hyperplasia (CLH), also known as cutaneous pseudolymphoma, is a spectrum of benign conditions characterized by reactive B‐ and T‐cell cutaneous lymphocytic infiltrates. B‐cell lymphoid proliferations are a heterogenous group of non‐neoplastic cutaneous diseases that must be histopathologically distinguished from cutaneous B‐cell lymphomas. These proliferations can be observed as reactive phenomena to infections, medications, allergens, neoplasms, and more. Furthermore, there are many inflammatory conditions that present with reactive B‐cell infiltrates, including actinic prurigo, Zoon balanitis, Rosai‐Dorfman disease, and cutaneous plasmacytosis. This review summarizes multiple cutaneous B‐cell lymphoid proliferations within the major categories of reactive and disease‐associated CLH. Further we discuss major discriminating features of atypical CLH and malignancy. Understanding the specific patterns of B‐cell CLH is essential for the proper diagnosis and treatment of patients presenting with such lesions.

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Histologic Features of Syphilitic Gastritis: A Rare but Resurging Imitator of Common Diseases

Assarzadegan

Fang

Voltaggio

et al. 2023

American Journal of Clinical Pathology

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Objectives The range of histopathologic features of gastric syphilis is not well described. Here we describe the clinicopathologic findings of eight patients with syphilitic gastritis. Methods A search of our Pathology Data System (2003-2022) and multiple other institutions identified eight patients with syphilitic gastritis. Clinical information, pathology reports, and available slides were reviewed. Results Lesions predominated in middle-aged adults (mean age, 47.2 years; range, 23-61 years) with a propensity for men (n = 7). Three patients had a documented history of human immunodeficiency virus. Clinical presentations included weight loss, abdominal pain, hematochezia, fever, dyspepsia, nausea and vomiting, hematemesis, anemia, and early satiety. Endoscopic findings included ulcerations, erosions, abnormal mucosa, and nodularity. All specimens shared an active chronic gastritis pattern with intense lymphohistiocytic infiltrates, variable plasma cells, and gland loss. Prominent lymphoid aggregates were seen in four specimens. The diagnosis was confirmed either by immunostain for Treponema pallidum (n = 7) or by direct immunofluorescence staining and real-time polymerase chain reaction (n = 1). All patients with available follow-up data showed resolution of symptoms after antibiotic therapy (n = 4). Conclusions Recognition of the histologic pattern of syphilitic gastritis facilitates timely treatment, prevents further transmission, and avoids unnecessarily aggressive treatment.

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A case of secondary syphilis masquerading as cutaneous lymphoma

Cited by 4 publications

References 10 publications

Secondary syphilis resembling lymphoma‐like nodules in a 59‐year‐old woman

Secondary syphilis resembling lymphoma‐like nodules in a 59‐year‐old woman

Cutaneous reactive B‐cell lymphoid proliferations

Histologic Features of Syphilitic Gastritis: A Rare but Resurging Imitator of Common Diseases

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