A case of sensorineural deafness following ingestion of sildenafil

Mukherjee, Barid B.; Shivakumar, T

doi:10.1017/s0022215106005512

Cited by 46 publications

(47 citation statements)

References 7 publications

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“…However, a few studies to date have reported side effects of sildenafil that include flushing, headache, nasal congestion, heartburn, and non-arteritic anterior ischemic optic neuropathy. [3][4][5][6][7] Recently, sildenafil was reported to induce profound bilateral sensorineural hearing loss (SNHL) in a 44-year-old male patient following ingestion at 50 mg/d doses for 15 d. 8) SNHL is a type of hearing loss that involves the auditory nerve, inner ear, or central processing centers of the brain. SNHL can be evaluated as mild, moderate, or severe, and can cause complete deafness.…”

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confidence: 99%

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hong

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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Sildenafil is widely administered for the treatment of erectile dysfunction. Recently, sensorineural hearing loss following the ingestion of sildenafil was reported in one male patient. We examined hearing in mice that were administered high doses of sildenafil for up to 105 d. To assess hearing impairment, we evaluated auditory brainstem responses, auditory middle latency responses, and otoacoustic emissions. At high doses, sildenafil increased the hearing threshold shift of auditory brainstem responses. High-dose sildenafil treatment also resulted in delayed latency of both auditory brainstem responses and auditory middle responses. Otoacoustic emissions differed between control and high-dose sildenafil groups with long-term treatment. Collectively, these data demonstrate that high-dose and long-term sildenafil administration can induce hearing impairment in mice.

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confidence: 99%

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hong

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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“…Such interventions include independent patients and physicians' exposure to a new commercial media campaigns in Israel on MayJune 2007 with the aim of raising the awareness towards ED, and studies that were published during and around the study period regarding rare, severe side effects of PDE5-inh medications. 8,9 However, these processes most probably acted in both groups in both ways, and thus it is hard to assess their influence over theses variables. ED diagnosis and medical treatment correlate with the patients' age, so that younger patients had a greater chance to be diagnosed with ED and to be given prescriptions for PDE5-inh.…”

Section: Discussionmentioning

confidence: 99%

Raising awareness for the diagnosis and treatment of erectile dysfunction in patients with high risk to develop ED

et al. 2009

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Prevalence of erectile dysfunction (ED) increases with age and is associated with chronic comorbidities, such as diabetes and hypertension. Even so, ED is underdiagnosed and undertreated. This study investigated the effect of raising awareness of ED diagnosis and treatment in a community setting by physicians' education. Thirty-nine primary care physicians participated in lectures by a trained sexologist, and 20 of them also received computerized lists of their high-risk patients. We matched a control group of 39 primary care physicians who did not receive the intervention; we thus followed 1959 patients in both intervention groups and 1903 patients in the control group. During the period of 6 months before the intervention and 6 months after the intervention, no significant differences were found between the groups in diagnosis of new ED patients, in phosphodiesterase-5 inhibitor prescriptions or in referrals to urologists. We therefore suggest that sporadic lectures and computerized patient lists do not significantly affect the physician's behavior.

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“…In the year 2007, an alarming report was published by Mukherjee and Shivakumar, in which a case of bilateral profound sensorineural hearing loss was described in 44-year-old man who took 50 mg/day of sildenafil for 2 weeks [23]. Based on that report, FDA issued a warning about possible sudden hearing loss among users of PDE5 inhibitors.…”

Section: Phosphodiesterase-5 (Pde5) Inhibitorsmentioning

confidence: 99%

Ototoxicity: Old and New Foes

Szczepek¹

2017

Advances in Clinical Audiology

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Drug-induced ototoxicity has been known for centuries. Already in the seventeenth century, hearing loss was described to be a side effect of quinine. The post-World War II pharmaceutical industry boomed with the production of aminoglycoside antibiotics followed by diuretics and cytostatic drugs. Wide-spread and long-term usage of these medications brought the knowledge about their unwanted ototoxic effects. In the last decades, several new drugs appeared on the shelves of pharmacies and the hearing loss or tinnitus have been among the side effects of many of them. However, the awareness of community about new ototoxic medications is still not sufficient. New ototoxic drugs may belong to the class of phosphodiesterase-5 (PDE5) inhibitors, used to improve microcirculation and to treat erectile dysfunction. Moreover, interferons used for the therapy of hepatitis B and C, common painkiller paracetamol and hydrocodone, synthetic opioid methadone and the inhibitors of reverse transcriptase were demonstrated to induce adverse effects on hearing. Lastly, hearing loss linked to immunosuppressive drugs was documented in patients undergoing organ transplantation. Making the patients aware of adverse drug reactions and offering them audiological monitoring and intervention should be considered by respective therapists.

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A case of sensorineural deafness following ingestion of sildenafil

Cited by 46 publications

References 7 publications

High Dosage Sildenafil Induces Hearing Impairment in Mice

High Dosage Sildenafil Induces Hearing Impairment in Mice

Raising awareness for the diagnosis and treatment of erectile dysfunction in patients with high risk to develop ED

Ototoxicity: Old and New Foes

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