A case of severe interstitial lung disease after COVID-19 vaccination

Kono, Alan T.; Yoshioka, Ryuji; Hawk, P; Iwashina, K; Inoue, Daisuke; Suzuki, Maki; Narita, Chihiro; Haruta, Koichi; Miyake, Akihiro; Yoshida, Hiroo; Tosaka, Naoki

doi:10.1093/qjmed/hcab263

Cited by 17 publications

(16 citation statements)

References 3 publications

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“…To date, seven cases of COVID‐19 mRNA vaccine‐associated ILD have been reported in the English literature (Table 1 ). 7 , 8 , 9 , 10 , 11 Symptom onset was within a few days after vaccination, and fever appeared in most cases. Two patients were intubated, but all patients responded to steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

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COVID‐19 mRNA vaccine‐related interstitial lung disease: Two case reports and literature review

Ishida

Hirakawa

et al. 2022

Respirology Case Reports

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The Pfizer‐BioNTech mRNA vaccine (BNT162b2) is an effective and well‐tolerated coronavirus disease 2019 (COVID‐19) vaccine. However, rare adverse events have been reported. We report two cases of COVID‐19 mRNA vaccine‐related interstitial lung disease (ILD). A 67‐year‐old man and a 70‐year‐old man with underlying ILD presented to our hospital with a few days of fever and respiratory symptoms after receiving the BNT162b2 vaccine. Drug‐related pneumonitis due to the COVID‐19 mRNA vaccine was diagnosed. One case was diagnosed with lymphocytic alveolitis by bronchoalveolar lavage fluid and transbronchial lung cryobiopsy. Both patients were successfully treated with corticosteroids, and they attended outpatient clinics thereafter. Although the safety and efficacy of COVID‐19 vaccines have been established, further studies are needed to estimate long‐term data and reports of rare adverse reactions. We present the clinical course of two cases, review previously published case reports on COVID‐19 mRNA vaccine‐related ILD and discuss the relevant findings.

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Section: Discussionmentioning

confidence: 99%

“…T A B L E 1 Clinical features of COVID-19 mRNA vaccine-related ILD and clinical outcomes Case Park et al 7 Yoshifuji et al 8 Kono et al 9 Shimizu et al 10 Shimizu et al 10 Shimizu et al 10 Matsuzaki et al…”

Section: Casementioning

confidence: 99%

COVID‐19 mRNA vaccine‐related interstitial lung disease: Two case reports and literature review

Ishida

Hirakawa

et al. 2022

Respirology Case Reports

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“…Yoshifuji et al described a case of ILD after vaccination [15]. Kono et al also reported a case of ILD after two weeks of COVID-19 immunization [16].…”

Section: Discussionmentioning

confidence: 99%

Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine

Khan¹,

Khattak²,

Rafiq³

et al. 2022

Cureus

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“…Some reports have associated BNT162b2 vaccination with acute exacerbations of interstitial pneumonia, whereas, in the UK, 108 incidences of Interstitial Lung Disease (ILD) have been linked to the vaccine [ 88 ]. ILD has rarely occurred after the administration of some drugs or vaccines, such as influenza, and, also, the first two cases of ILD appearing after COVID-19 vaccination were Asians [ 89 ].…”

Section: Mrna Vaccination Against Covid-19 and Diagnosis Of Spontaneo...mentioning

confidence: 99%

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

Mouliou

Dardiotis

2022

Diagnostics

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The novel mRNA vaccinations against COVID-19 are gaining worldwide attention for their efficacy, as well as the diagnosis of some post-vaccination-reported adverse reactions. In this state-of-the-art review article, we present the current evidence regarding mainly the diagnosis of spontaneous allergic reactions, the skin occurrences, the vascular, blood, endocrine and heart events, the respiratory reports, the gastrointestinal, hepatic and kidney events, the reproductive and pregnancy issues and the muscle events, as well as the ear, eye, neurologic and psychiatric events following mRNA vaccination against COVID-19. We further present some evidence regarding the mRNA strategies and we discuss our expert opinion on the knowns and the unknowns towards the topic.

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A case of severe interstitial lung disease after COVID-19 vaccination

Cited by 17 publications

References 3 publications

COVID‐19 mRNA vaccine‐related interstitial lung disease: Two case reports and literature review

COVID‐19 mRNA vaccine‐related interstitial lung disease: Two case reports and literature review

Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

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