A case of sinonasal paraganglioma with a different morphology: nine-year follow-up

Abstract

Paragangliomas are very occasionally located in the nasal cavity. In this article, we present a 32-year-old female case with a sinonasal paraganglioma with atypical histopathological morphology. In our case, sinonasal paraganglioma consisted of lipoblast-like vacuolated cells instead of the typical Zellballan histological pattern. The prognosis of a nasal paraganglioma is not very clear. The present article is important, as it describes the first case report of a sinonasal paraganglioma with atypical lipoblast-like vacuolated cells with a nineyear follow-up.

Nasal septum: an extremely unusual location for head and neck paraganglioma

“…Other markers are Synaptophysin, neuron specific Enolase and S-100 protein, the last one stains the peripheral sustentacular cells. 9 Chromogranin was negative in our case as extra-adrenal paragangliomas are usually non-functional.…”

Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

“…This pattern was observed in our case, but an uncommon morphology was described with lipoblast-vacuolated cells instead of the typical pattern [23]. Other variations in the tumor architecture include diffuse and trabecular growth patterns, extensive sclerosis that may mimic invasive carcinoma, and unusual vascular patterns that can mimic angiomas [51].…”

“…These are all hypervascular tumors, with contrast enhancement, presenting the classic “salt-and-pepper” appearance and variable patterns of intensity on MRI [5,10,20,21,22,23,24,25,26,27,28,29,30,31,32]. …”

Paraganglioma of maxillary sinus associated with Addison’s disease mimicking a vascular tumour: A case report

“…However, atypical morphology may be encountered. [11] This variability, however, creates a challenge for both treating physician and histopathologists alike, especially if there is an association with systemic disease, i.e. Cushing's syndrome or Addison's disease, as seen in our case.…”