A Case of Skull Base Mucormycosis with Osteomyelitis Secondary to Temporal Bone Squamous Cell Carcinoma

Safaya, A.; Batra, Kadambari; Capoor, Malini R.

doi:10.1177/014556130608501213

Cited by 8 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 68 studies included a total of 74 individual cases of fungal TBO (Tables 3 and 4) (8,12,24–89). The mean age (SD) was 55.5 (23.3) years, and 74.3% (55/74) were male.…”

Section: Resultsmentioning

confidence: 99%

Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review

et al. 2022

View full text Add to dashboard Cite

IntroductionTemporal bone osteomyelitis is an invasive infection most often caused by bacteria and associated with high mortality. Fungal etiologies are rare and little is known of the predictors of disease severity and outcomes in fungal temporal bone osteomyelitis.Materials and MethodsA scoping review was performed to determine what is known from the literature on how clinical, diagnostic, and treatment characteristics relate to patient outcomes in fungal temporal bone osteomyelitis. Using PRISMA guidelines, three databases were searched to identify all published cases of fungal temporal bone osteomyelitis. Data were extracted from each study, including clinical, diagnostic, and treatment characteristics, and outcomes.ResultsSixty-eight studies comprising 74 individual cases of fungal temporal bone osteomyelitis were included. All studies were case reports. There were high rates of diabetes, facial nerve palsy, infectious complications, and need for surgical intervention, as well as a significant delay in the evaluation and diagnosis of fungal temporal bone osteomyelitis. Disease recovery was greater in patients presenting with otorrhea, comorbid diabetes, and in those without facial nerve palsy.DiscussionMany of the defining characteristics of fungal temporal bone osteomyelitis remain unknown, and future reports should focus on determining factors that improve timely diagnosis and treatment of fungal TBO in addition to identifying prognostic indicators for outcomes and survival.

show abstract

“…The 68 studies included a total of 74 individual cases of fungal TBO (Tables 3 and 4) (8,12,24–89). The mean age (SD) was 55.5 (23.3) years, and 74.3% (55/74) were male.…”

Section: Resultsmentioning

confidence: 99%

Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This deadly affection is increasingly emerging, considered the third most common opportunistic fungal infection in immunocompromised and diabetic patients [156][157][158]. Rhizopus species are the most common causative organisms, followed by Mucor and Absidia from the order of Mucorales.…”

Section: Mucormycosismentioning

confidence: 99%

“…As other forms of fungal skull osteomyelitis, mucormycosis is often considered only following failure of antibacterial therapy [168]. The significant morbidity of skull mucormycosis is consisted with previous localization of this opportunistic fungus including diabetes mellitus, chronic leukemia, chronic renal failure, viral hepatitis, severe malnutrition or any other state of immune suppression [158,159,163,168,169]. Importantly, however, skull osteomyelitis due to mucormycosis may also occur in immunocompetent individuals [170,171].…”

Section: Mucormycosismentioning

confidence: 99%

Cranial Osteomyelitis

Akhaddar¹

2016

View full text Add to dashboard Cite

“…Most invasive fungal infections occur in patients with prolonged neutropenia, critically ill patients in intensive care, patients undergoing chemotherapy for solid tumors, patients with acquired immunodeficiency syndrome (AIDS), and patients who have received an organ transplant. A secondary infection by an opportunistic fungus in an already immunocompromised patient is not easy to diagnose or treat, and the prognosis for patients with this life-threatening complication is poor (Safaya et al, 2006).…”

Section: Fungal Skull Osteomyelitismentioning

confidence: 99%

“…A few reports of chronic invasive mucormycotic sinusitis causing SBO have appeared in the literature (Bahna et al, 1980;Finn & Farmer, 1982). Mucormycosis is the third most common opportunistic fungal infection in immunocompromised and diabetic patients (Safaya et al, 2006). However, skull base involvement is generally a late and uncommon finding in this situation.…”

Section: Mucormycosis Sbomentioning

confidence: 99%

Skull Osteomyelitis

Soo¹

2012

Osteomyelitis

View full text Add to dashboard Cite

Bone lesions resembling tertiary syphilis caused by Treponema pallidum or another of the treponematoses have been observed in nearly every Andean culture from Peru and Chile, dating back nearly 8000 years (Gerstzen et al., 1998). The lesions are similar in each case, with periostitis, osteitis, and osteomyelitis attacking the skull and the long bone, particularly the tibia. This tibial involvement results in the classic "saber shin". Several of the skulls observed with such lesions had been "treated" during life by repeated trephination using a scraping technique. 2.1.2 Greek and early Byzantine period The intellectual evolution of neurological surgery originated in the golden age of Greece with the founding of the Alexandrian school in 300 BC. Because of both sporting injuries, in particular gladiator injuries, and wars, head injuries appear to have been plentiful, and provided opportunities to develop neurosurgical skills (Goodrich & Flamm, 2011). In this early era of medicine, the risk of infection, lack of antiseptic technique, and minimal anesthesia prevented generations of surgeons from performing any serious or aggressive surgical intervention for head injury (Goodrich & Flamm, 2011). Galen of Pergamon (AD 129-200) detailed a safer and more reliable use of the trephine, and in particular argued for continuous irrigation during trephination to avoid delivering excessive heat and injury to the underlying brain (Goodrich, 2005). Paul of Aegina (AD 625-690), trained in the Alexandrian school, was the last great Byzantine physician. His wound management was quite sophisticated for prevention of infection. He used wine (helpful in antisepsis, although this concept was then unknown) (Goodrich, 2005). 2.1.3 Medieval Europe Inventive medieval surgeon Theodoric Borgognoni of Cervia (1205-1298) is remembered as a pioneer in the use of the aseptic technique-not the "clean" aseptic technique of today, but rather a method based on avoidance of "laudable pus". He attempted to discover the ideal conditions for good wound healing, and concluded that they comprised control of bleeding, removal of contaminated or necrotic material, avoidance of dead space, and careful application of a wound dressing bathed in wine (Goodrich & Flamm, 2011). Control of bleeding, removal of contaminated or necrotic material, and avoidance of dead space are principles that can also apply in today's neurosurgical operations. He also argued for primary closure of all wounds when possible and avoiding "laudable pus" (Goodrich & Flamm, 2011). Lanfranchi of Milan (1250-1306) noted that the head should be shaved prior to surgery to prevent hair from getting into the wound and interfering with primary healing. Today, most neurosurgeons also shave hair before an operation. However, the time of shaving is currently controversial. When dealing with depressed skull fractures, Lanfranchi advocated putting wine into the depression to assist healing (Goodrich & Flamm, 2011). Guy de Chauliac (1300-1368) was clearly the most influential European surgeon of the ...

show abstract

A Case of Skull Base Mucormycosis with Osteomyelitis Secondary to Temporal Bone Squamous Cell Carcinoma

Abstract: We describe an unusual case in which a 35-year-old man presented with skull base mucormycosis with osteomyelitis secondary to squamo us cell carcinoma of the temporal bone. We also review the literature on the clinical characteristics, diagnosis, and treatment of mucormycosis.

Cited by 8 publications

References 5 publications

Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review

Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review

Cranial Osteomyelitis

Skull Osteomyelitis

Contact Info

Product

Resources

About