A case of SLE with lupus nephritis occurring in the course of Crohn's disease.

Sugimoto, Masakuni; Sato, Yuji; Kumagai, Yoshihiro; Suenaga, Matsuhiko; Hashimoto, Hiroshi; Hirose, Shunichi

doi:10.2169/naika.78.583

“…Our two cases were in this interval. To the best of our knowledge, two cases of association between LN and CD have been reported [6,7], and one of them showed favorable renal response to Infliximab [6]. The SLE of one of these two patients preceded the CD [6] while the SLE of the other patient followed the CD [7].…”

Section: Shor Et Al Have Shown That the Prevalence Of CD In Sle Is Highestmentioning

confidence: 83%

Untitled

2019

AJGH

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Introduction :The systemic lupus erythematosus (SLE) is usually associated with other autoimmune and dysimmune diseases. The coexistence of SLE and Crohn's disease (CD), as an Inflammatory bowel disease, in the same patient is extremely rare. The presence of lupus nephritis during this association is even rarer.Case Report : We report two observations, a 56-year-old woman and a 37-year-old man. The first was followed for a SLE and after 3 years she developed a CD. The second was followed for a CD and after 4 years he developed a SLE. Both patients presented the second disease at the time that the first was in remission. For both patients, the clinical manifestation of the CD was diarrhoea with ileocecal stenosis. Both patients presented with proliferative lupus nephritis. They had positive anti-DNA antibodies. Conclusion :Admittedly, the association between the SLE and the CD is extremely rare, especially the presence of lupus nephritis, a screening of one of these diseases in presence of the other is thus justified in front of any several extraintestinal manifestation in CD and any gastrointestinal manifestation in a well-controlled SLE.

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“…The LN class would be proliferative, because our two patients had a class III and that case of Principi was class IV [6]. We do not have enough detail of Sugimoto's observation because it was written in Japanese [7].…”

Section: Shor Et Al Have Shown That the Prevalence Of CD In Sle Is Highestmentioning

confidence: 89%

“…The coexistence of SLE and CD in the same patient is extremely rare (<0.4%) [5]. Even rarer is the association between lupus nephritis (LN) and CD, with only two cases reported to date [6,7]. A review study corroborated that SLE was associated with comorbid CD (OR 2.23) [8].…”

Section: Introductionmentioning

confidence: 99%

Coexistence of Crohn’s Disease and Systemic Lupus Erythematosus with Lupus Nephritis : About Two Cases

Somaï

¹

2019

AJGH

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Introduction :The systemic lupus erythematosus (SLE) is usually associated with other autoimmune and dysimmune diseases. The coexistence of SLE and Crohn's disease (CD), as an Inflammatory bowel disease, in the same patient is extremely rare. The presence of lupus nephritis during this association is even rarer.Case Report : We report two observations, a 56-year-old woman and a 37-year-old man. The first was followed for a SLE and after 3 years she developed a CD. The second was followed for a CD and after 4 years he developed a SLE. Both patients presented the second disease at the time that the first was in remission. For both patients, the clinical manifestation of the CD was diarrhoea with ileocecal stenosis. Both patients presented with proliferative lupus nephritis. They had positive anti-DNA antibodies. Conclusion :Admittedly, the association between the SLE and the CD is extremely rare, especially the presence of lupus nephritis, a screening of one of these diseases in presence of the other is thus justified in front of any several extraintestinal manifestation in CD and any gastrointestinal manifestation in a well-controlled SLE.

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“…We identified 17 patients who developed concomitant SLE and CD; 11 in the English-language literature [1,2,[6][7][8][9][10][11][12][13][14][15] and 6 in the Japanese-language literature [16][17][18][19][20][21]. The patient characteristics are summarized in Table 1.…”

Section: Ibd Subgroup: Cases Of Sle and CDmentioning

confidence: 99%

“…Other presentations of SLE and CD have also been reported, including familial CD, in which SLE developed after CD [6]; a female with SLE and CD, who developed rheumatoid arthritis and Sjögren's syndrome [16]; and 2 cases associated with lupus nephritis [15,17].…”

Section: Ibd Subgroup: Cases Of Sle and CDmentioning

confidence: 99%