A case of spontaneous regression of small cell lung cancer with progression of paraneoplastic sensory neuropathy

Hirano, Satoshi; Nakajima, Yoshifumi; Morino, Eriko; Fujikura, Yuji; Mochizuki, Makoto; Takeda, Yuichiro; Sugiyama, Haruhito; Kobayashi, Nobuyuki; Tanaka, Keiko; Kudo, Kohsuke

doi:10.1016/j.lungcan.2007.05.005

Cited by 22 publications

(14 citation statements)

References 12 publications

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“…Hirano et al14 reported an association of paraneoplastic syndrome with SR of small cell cancer; 3 of 8 cases had paraneoplastic sensory neuropathy. Anti-Hu, anti-Yo, and anti-Ri antibodies can be found in patient with paraneoplastic sensory neuropathy, and they exhibit cross-reactivity to both tumor and nervous tissue 14…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Endobronchial Carcinoid Tumor

Venkatram

Sinha²,

Hashmi³

et al. 2017

Journal of Bronchology &Amp; Interventional Pulmonology

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Spontaneous regression (SR) of cancer refers to partial or complete disappearance of a malignant tumor in the absence of treatment or in the presence of therapy, which is considered inadequate to exert a significant influence on the growth of neoplastic disease. SR is a very rare phenomenon in primary lung cancers. Follow-up of these patients is generally either by imaging or bronchoscopy. We present a patient with SR of an endobronchial carcinoid, followed by serial bronchoscopies and biopsy over a 24-month period.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Endobronchial Carcinoid Tumor

Venkatram

Sinha²,

Hashmi³

et al. 2017

Journal of Bronchology &Amp; Interventional Pulmonology

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“…However, he had continued his lifestyle as same as before, and no additional treatment was started, including so-called health foods and supplements that may have immunomodulatory activity. In some clinical settings such as paraneoplastic syndromes, particularly paraneoplastic neurological syndromes, spontaneous regression of small cell lung cancer without treatment has been reported [14][15][16], which suggests an immune response directed against both the nervous system and the cancer [17]. In the current case, however, histology was squamous cell carcinoma and no neurological symptom was observed.…”

Section: Discussionmentioning

confidence: 58%

Delayed onset, Long-term Efficacy of S-1 Monotherapy for an Elderly Patient with Squamous Cell Lung Cancer

Kanaji

Nanki²,

Tadokoro³

et al. 2014

Chemotherapy (Los Angel)

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The efficacy of S-1 monotherapy as a 2 nd -line regimen for elderly patients with non-small cell lung cancer (NSCLC) has not been reported, nor has delayed onset regression after temporary progression of tumor during an identified therapeutic regimen. Here we report a 78-year-old man was diagnosed with T3N3M1b (BRA), stage IV squamous cell lung cancer. His primary lesion progressed after whole brain irradiation and 4 cycles of 1 st -line chemotherapy with docetaxel. S-1 monotherapy was prescribed as the 2 nd -line treatment. Each cycle of chemotherapy comprised 14 days of S-1 (40 mg, twice daily) followed by 14 drug-free days. After 6 months of S-1 monotherapy, primary and metastatic lesions had started regressing significantly. He continued S-1 monotherapy for 19 months (20 cycles) with a comfortable daily life until reaching progressive disease. S-1 monotherapy as a 2 nd -line could be a therapeutic option for elderly patients with NSCLC. Moreover, long-term use of S-1 might be worth trying if adverse events and tumor growth are tolerable and other anti-cancer drugs are not applicable, because S-1 has a potential for delayed onset efficacy.

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“…Everson divides SR into four categories: primary tumor regression, metastatic tumor regression (primary focus is defined pathologically), metastatic tumor regression (no pathological diagnosis of primary tumor), and radiologically considered metastasis tumor regression . SR is a very rare phenomenon , especially in the case of squamous cell lung cancer, with very few reports in the literature to date .…”

Section: Introductionmentioning

confidence: 99%