2007
DOI: 10.5833/jjgs.40.456
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A Case of Spontaneously Ruptured Anaplastic Carcinoma (Giant Cell Type) of the Pancreas with Intraabdominal Hemorrhage

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Cited by 9 publications
(6 citation statements)
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“…Abdominal pain, back pain, weight loss, fever, anorexia, and jaundice can be the initial symptoms [ 2 ]. About half of the patients show elevation of WBC count and C-reactive protein (CRP) for G-CSF production, and about 60% of the patients show elevation of CA19-9 [ 4 ]. Since the tumor is generally large at onset, and many cases have wide-spread hematogenous metastasis and lymphogenous metastasis, the prognosis is extremely unfavorable.…”
Section: Discussionmentioning
confidence: 99%
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“…Abdominal pain, back pain, weight loss, fever, anorexia, and jaundice can be the initial symptoms [ 2 ]. About half of the patients show elevation of WBC count and C-reactive protein (CRP) for G-CSF production, and about 60% of the patients show elevation of CA19-9 [ 4 ]. Since the tumor is generally large at onset, and many cases have wide-spread hematogenous metastasis and lymphogenous metastasis, the prognosis is extremely unfavorable.…”
Section: Discussionmentioning
confidence: 99%
“…They typically show high contrast enhancement in early phase on dynamic study, which can differentiate from undifferentiated carcinoma. Additionally, elevation of WBC count and CRP level can help the diagnosis of undifferentiated carcinoma [ 4 ]. However, in the cases with lack of these characteristics, differential diagnosis from early undifferentiated carcinoma would be difficult.…”
Section: Discussionmentioning
confidence: 99%
“…Unlike the original undifferentiated carcinoma, which is very aggressive and frequently metastasizes to lymph nodes or other organs, UCPOGC is known to be less aggressive, the prognosis of which is better than invasive ductal carcinoma of the pancreas [3]. Clinical presentation of UCP is nonspecific, including abdominal pain, a palpable mass, weight loss, etc, and tumor markers including CA 19-9 elevate in about half of the patients [4], [5]. UCPOGC is usually large, moderately to highly hypervascular, and exophytic tumors with large areas of intratumoral necrosis and hemorrhage [4], [6], [7].…”
Section: Discussionmentioning
confidence: 99%
“…The clinical manifestations are not different between APC and PDAC; back pain, weight loss, and abdominal distention are the major symptoms. There have been few case reports of APC that presented with the rupture of the tumor into the peritoneal cavity [7,8]. Considering the pathological nature of APC, which grows rapidly and is rich vascularity, it is plausible that spontaneous rupture of the tumor may occur, albeit infrequently.…”
Section: Discussionmentioning
confidence: 99%
“…The prognosis of APC is poorer than that of PDAC because of its aggressive nature and extensive hematogenous dissemination. One-year fatality rates are 71%, and 5-year survival rates are 9.6% only [7]. The major metastatic lesion of APC presents in the liver (87%), followed by the lungs (73%), adrenal glands (60%), kidneys (47%), bones (40%), heart (33%), and thyroid gland (20%) [2].…”
Section: Discussionmentioning
confidence: 99%