A case of successful double sequential bone marrow and kidney transplantations in a patient with multiple myeloma

Khoriaty, Rami; Otrock, Zaher K.; Medawar, Walid; Khauli, Raja B.; Bazarbachi, Ali

doi:10.1093/ndt/gfl403

Cited by 10 publications

(5 citation statements)

References 31 publications

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“… 12 Therefore, data on KTx in patients with MM are limited and mostly come from single case reports and small series. 7 , 8 , 9 , 10 , 11 , 12 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 The largest of these reported on 13 patients across all of France, 12 who underwent KTx but only 10 of them had MM at the time of KTx. This series is the largest single-center study on the outcomes of patients with symptomatic MM after kidney transplant.…”

Section: Discussionmentioning

confidence: 99%

Kidney Transplant Outcomes of Patients With Multiple Myeloma

Heybeli

Bentall

Alexander³

et al. 2022

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Kidney Transplant Outcomes of Patients With Multiple Myeloma

Heybeli

Bentall

Alexander³

et al. 2022

Kidney International Reports

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“…[7] Subsequent renal transplantation is even rarer but has been reported from few centers in younger patients with good performance status. [8910]…”

Section: Discussionmentioning

confidence: 99%

Sequential, autologous hematopoietic stem cell transplant followed by renal transplant in multiple myeloma

Bhowmik

Kumar

et al. 2017

Indian J Nephrol

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A 30-year-old female was symptomatic with headache, fatigue, and weakness since October 2011 and was told to have anemia. In January 2012, she was admitted outside with pulmonary edema. Investigations revealed advanced azotemia, anemia, and hypercalcemia. Urine showed 2 + proteins and 30–35 red blood cells. There was no history of oral ulcers, rash, Raynaud's phenomenon, or hemoptysis. She was evaluated for causes of rapidly progressive “renal failure.” Hemolytic work-up; antinuclear antibody, double-stranded DNA, and anti-neutrophil cytoplasmic antibody were negative. Kidney biopsy was done and interpreted as acute interstitial nephritis with hyaline casts. She was started on hemodialysis and treated with steroids and cyclophosphamide. She came to our institute in January 2012. Investigations showed evidence of paraproteinemia with kappa restriction. Bone marrow showed 15% plasma cells. Kidney biopsy was reviewed and was diagnostic of cast nephropathy. She was treated with 6 monthly cycles of dexamethasone and bortezomib. She achieved complete remission in July 2012. Maintenance doses of bortezomib were continued until May 2014. Autologous bone marrow transplantation was performed on June 06, 2014. Monthly, bortezomib was continued till April 2015. Subsequently, workup for renal transplantation was started with her father as her donor. Test for sensitization was negative. Renal transplantation was done on January 1, 2016, with prednisolone, mycophenolate, and tacrolimus. She achieved a serum creatinine of 0.6 mg% on the 4th postoperative day. Thereafter, she continues to remain stable.

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“…Combined HSCT, predominantly autologous HSCT, and renal transplantation have been performed for patients having various hematological disorders such as plasma cell dyscrasias [198][199][200][201][202]. Patients with MM having ESRD, either on regular hemodialysis or not, can be offered not only HSCT but also combined HSCT and renal transplantation either simultaneously or sequentially [198,199,[203][204][205][206].…”

Section: Management Of MM Patients Having Renal Failurementioning

confidence: 99%

Hematopoietic Stem Cell Transplantation in Multiple Myeloma in the Era of Novel Therapies

Al-Anazi¹

2019

Update on Multiple Myeloma

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Multiple myeloma is the second commonest hematologic malignancy. It is characterized by neoplastic proliferation of a single clone of plasma cells in the bone marrow producing a monoclonal immunoglobulin and ultimately causing various complications and organ dysfunction. Over the last 10 years, management of multiple myeloma has dramatically changed due to the introduction of several novel therapies that have improved the disease outcome and prognosis, as well as the quality of life of patients with myeloma due to their safety, tolerability and efficacy. Additionally, the widespread utilization of autologous hematopoietic stem cell transplantation, which is still the standard of care for transplant-eligible patients, and the implementation of new therapeutic strategies such as drug combinations in addition to consolidation and maintenance therapies have resulted in further improvements in response rates and survival in patients with multiple myeloma. This book chapter will be an update on the novel therapies and the recent treatment strategies in myeloma. The role of stem cell treatments in the era of novel therapies will be discussed thoroughly.

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A case of successful double sequential bone marrow and kidney transplantations in a patient with multiple myeloma

Cited by 10 publications

References 31 publications

Kidney Transplant Outcomes of Patients With Multiple Myeloma

Kidney Transplant Outcomes of Patients With Multiple Myeloma

Sequential, autologous hematopoietic stem cell transplant followed by renal transplant in multiple myeloma

Hematopoietic Stem Cell Transplantation in Multiple Myeloma in the Era of Novel Therapies

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