A Case of Synchronous Radiation-induced Glioblastoma and Meningioma diagnosed 41 Years after Radiation Therapy for Anaplastic Ependymoma

Takase, Kaoru; Mishima, Hiroyuki; Ayabe, Junichi; Watanabe, Masahide; Tsuchiya, Yusuke; Maruyama, Takumi; Masuko, Yu; Tateishi, Kensuke; Tanaka, Yoshihide

doi:10.7887/jcns.30.305

Cited by 1 publication

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“…30 Simultaneous RIM and RIG were found in 1 patient. 31 The mean radiation dose for the primary disease was 45.7 ± 15.5 Gy.…”

Section: Patients With Different Types Of Metachronous and Simultaneo...mentioning

confidence: 98%

Characteristics of radiation-induced brain tumors: case series and systematic review

Onishi,

Yamasaki,

Kinoshita

et al. 2024

Journal of Neurosurgery

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OBJECTIVE Radiation therapy (RT) improves the outcome of patients with cancer but introduces the risk of radiation-induced neoplasms in cancer survivors. The most common radiation-induced brain tumors (RIBTs) are gliomas (RIGs), meningiomas (RIMs), and sarcomas (RISs). To investigate the characteristics of these RIBTs, the authors conducted a comprehensive review and analysis of their case series and relevant cases from the literature. METHODS Sixteen patients in the case series and 941 patients from the literature who previously underwent cranial irradiation were included in this study. The age at irradiation for primary disease was recorded, and the latency period from irradiation to the development of RIBT and the median overall survival (OS) of patients with RIBTs were analyzed using the Kaplan-Meier method. Patients were stratified by age at the time of irradiation (pediatric vs nonpediatric) and the irradiation dose (higher vs lower dose), and latency and OS were compared using the log-rank test. RESULTS Among patients with RIBTs, 23.4% underwent radiation at < 5 years of age, and 46.6% underwent RT in the 1st decade of life. The median ages at cranial irradiation were 8.4 (IQR 4.1–16) years in patients with RIMs, 9 (IQR 5–23) years in patients with RIGs, and 27.7 (IQR 13.8–40) years in patients with RISs. The median latency period from irradiation to the development of RIM was significantly longer than that to the development of RIG and RIS (RIM: 20 years, RIG: 9 years, RIS: 10 years; p < 0.0001). The latency period was shorter in the nonpediatric patient group with RIMs (p = 0.047). The OS was significantly longer in patients with RIMs than in those with RIGs and RISs (RIM: not reached, RIG: 11 months, RIS: 11 months; p < 0.0001). The OS of patients with RIMs and RIGs was significantly shorter in patients who received higher radiation doses (p = 0.0095 and p = 0.0026, respectively). CONCLUSIONS The prognosis was poor and worse for patients with RIGs and RISs than for those with RIMs, and patients with RIBTs who underwent higher-dose irradiation for primary disease had poor prognoses. Because RIBTs develop more than a decade after cranial irradiation, long-term follow-up is crucial.

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“…30 Simultaneous RIM and RIG were found in 1 patient. 31 The mean radiation dose for the primary disease was 45.7 ± 15.5 Gy.…”

Section: Patients With Different Types Of Metachronous and Simultaneo...mentioning

confidence: 98%

Characteristics of radiation-induced brain tumors: case series and systematic review

Onishi,

Yamasaki,

Kinoshita

et al. 2024

Journal of Neurosurgery

View full text Add to dashboard Cite

show abstract

A Case of Synchronous Radiation-induced Glioblastoma and Meningioma diagnosed 41 Years after Radiation Therapy for Anaplastic Ependymoma

Cited by 1 publication

References 23 publications

Characteristics of radiation-induced brain tumors: case series and systematic review

Characteristics of radiation-induced brain tumors: case series and systematic review

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