A case of systemic sclerosis complicated by autoimmune hemolytic anemia

Katsumata, Kazuaki

doi:10.1007/s10165-006-0480-8

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…The hemoglobin levels expressed in our case could possibly be due to a combination of factors, including a poor diet seen predominantly in women in the Indian subcontinent, along with other factors that could possibly be malabsorption from the gut due to fibrosis leading from diffuse scleroderma [ 15 ]. We are sure these could not be due to hemolytic anemia, even though this has been seen in certain case reports with similar presentations and antibody profiles [ 16 ]. Anemia is significant, as it has been proven to be a marker for more severe organ damage [ 17 ] in systemic sclerosis.…”

Section: Discussionmentioning

confidence: 84%

A Rare Case of Polymyositis and Systemic Sclerosis Overlap Syndrome: Diagnosis and Treatment

Uddin¹,

Vempati²,

Bhavanam³

et al. 2023

Cureus

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Diffuse scleroderma is a kind of scleroderma in which the immune system malfunctions, leading to excessive production of collagen in the skin and a variety of organ abnormalities. Based on previously recognized criteria, overlap syndrome is a disorder in which two or more medical illnesses are documented in a single patient. These syndromes are significantly more prevalent in illnesses with mixed connective tissue. In this case report, we present a patient with overlapping systemic sclerosis and polymyositis symptoms. The treatment and diagnosis of this extremely uncommon condition are discussed in further detail.

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Section: Discussionmentioning

confidence: 84%

A Rare Case of Polymyositis and Systemic Sclerosis Overlap Syndrome: Diagnosis and Treatment

Uddin¹,

Vempati²,

Bhavanam³

et al. 2023

Cureus

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“…Microangiopathic haemolytic anaemia which is caused by fragmentation of RBCs passing through microvessels is a characteristic finding in renal crisis seen in scleroderma [2]. Autoimmune haemolytic anaemia is a rare manifestation in systemic sclerosis and it has been described in several case records [9]. Our patient had severe Coombs' negative autoimmune haemolytic anaemia without evidence of any renal disorder or hypertension.…”

Section: Discussionmentioning

confidence: 91%

Systemic Sclerosis Presenting with Simultaneous Retinal Vasculitis in One Eye and Optic Neuritis in the other along with Severe Immune Haemolytic Anaemia

Moulick

Sarkar

Jana

et al. 2013

JCDR

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A 40-year-old housewife presented with dimness of vision in both eyes, which she had for 10 days. Dimness of vision started in the right eye, it progressed over two to three days and it then affected her left eye acutely. It was painless and there was no history of red eye, fever, trauma or toxin exposure. She attended eye OPD of a medical college hospital. Her vision was 6/24 in right eye and finger counting at one foot in left eye. Intra-ocular pressure was normal. The anterior chamber was clear. Ophthalmoscopy revealed evidence of retinal vasculitis in her right eye, which was manifested by superficial retinal haemorrhages, cotton wool spots, retinal venous dilatation; and an altered macular reflex in left eye [Table/ Fig-1]. A cranial CT (Computed Tomography) scan did not reveal any abnormality. DFA (Digital Fluorescent Angiography) revealed features suggestive of retinal vasculitis …. in right eye and a normal angiogram of left eye. VEP (Visual Evoked Potential) showed features of optic nerve demyelination on left side, which was suggested by a prolonged P1 00 latency with a normal pattern on right side.She also complained of a progressive generalized weakness and fatigue over the same period and was referred to medical OPD for evaluation. She had no joint pain or swelling, dysphagia, chest pain, cough, fever or overt blood loss. There was no history of Raynaud's phenomenon. She had regular menstrual bleeding, with an average duration of three days and a normal flow. There was no significant past illness. She was married and was living with her husband and two sons. She had no history of abortions.On examination, she was found to have severe pallor and mild jaundice but no lymphadenopathy or hepatosplenomegaly. Her blood pressure was 122/78 mmHg (right arm supine). There was a thick patch of skin below her right eye which she had not noticed earlier [Table/ Fig-2]. The cardiac and respiratory system examinations were normal and nervous system did not have any abnormality apart from dimness of vision. Her initial investigation reports are tabulated in [Table/ Fig-3].Serum fT4 was 1.5 ng/dl; TSH was 2.88 micro IU/ml. ASO titre and Rheumatoid factor were negative. Urine RE did not reveal any abnormality and urine was negative for bile salts and bile pigments. Blood G-6PD level was 10.2 u/g Hb. Direct agglutination test (Coombs) was negative. Malarial Antigen was negative for both Pl. vivax and Pl. falciparum. Abdominal ultrasound revealed internal Medicine section aBstRaCt Systemic Sclerosis (SSc) is a connective tissue disorder which involves multiple systems in a chronic progressive manner. Micro-angiopathic haemolytic anaemia is a distinguished feature of "scleroderma renal crisis", which is manifested by severe hypertension, a rapidly progressing renal dysfunction and hyperreninaemia and is seen in patients with an early, diffuse form of the disease. A nervous system involvement is rare, though entrapment neuropathies have been reported. Who presented with a sequential loss of vision in both eyes; due to r...

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Anemia and Thrombocytopenia

Bagnato

Fürst

2020

In Clinical Practice

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A case of systemic sclerosis complicated by autoimmune hemolytic anemia

Cited by 5 publications

References 11 publications

A Rare Case of Polymyositis and Systemic Sclerosis Overlap Syndrome: Diagnosis and Treatment

A Rare Case of Polymyositis and Systemic Sclerosis Overlap Syndrome: Diagnosis and Treatment

Systemic Sclerosis Presenting with Simultaneous Retinal Vasculitis in One Eye and Optic Neuritis in the other along with Severe Immune Haemolytic Anaemia

Anemia and Thrombocytopenia

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