A case of thrombocytopenia associated with the use of hydroxychloroquine following open heart surgery

Demir, Deniz; Öçal, F.; Abanoz, Mustafa; Dermenci, Hasan

doi:10.1016/j.ijscr.2014.11.052

Cited by 14 publications

(13 citation statements)

References 9 publications

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“…According to the experimental results shown in Table 13 , one of the most common side effects related to the use of Hydroxychloroquine is 'Thrombocytopenia'. This result is also supported by past studies 52 . It may also cause dizziness due to its use with 33 different drugs.…”

Section: Resultssupporting

confidence: 91%

Identifying side effects of commonly used drugs in the treatment of Covid 19

Aygün

Kaya

Alhajj

2020

Sci Rep

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To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.

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Section: Resultssupporting

confidence: 91%

Identifying side effects of commonly used drugs in the treatment of Covid 19

Aygün

Kaya

Alhajj

2020

Sci Rep

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“…According to the experimental results shown in Table 13, one of the most common side effects related to the use of Hydroxychloroquine is 'Thrombocytopenia'. This result is also supported by past studies, e..g, (Demir et al, 2014). It may also cause dizziness due to its use with 33 different drugs.…”

Section: Hydroxychloroquinesupporting

confidence: 79%

Identifying Side Effects of Some Drugs Used in Covid-19 Treatment

Aygün

Kaya

Alhajj

2020

Preprint

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To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. Organ systems and diseases in which these 8 drugs cause the most negative effects have been identified. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.

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“…Also, hydroxychloroquine, azithromycin, and enoxaparin treatment have been started in most countries when COVID-19 is suspected. These drugs can cause thrombocytopenia 15,16 . Another reason for the difference between studies may be that thrombocytopenia caused by drugs and thrombocytopenia caused by the disease present an intricate structure.…”

Section: Discussionmentioning

confidence: 99%

Effect of COVID-19 on platelet count and its indices

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Kocayiğit

Okan

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY BACKGROUND Easily accessible, inexpensive, and widely used laboratory tests that demonstrate the severity of COVID-19 are important. Therefore, in this study, we aimed to investigate the relationship between mortality in COVID-19 and platelet count, Mean Platelet Volume (MPV), and platelet distribution width. METHODS In total, 215 COVID-19 patients were included in this study. The patients were divided into two groups. Patients with room air oxygen saturation < 90% were considered as severe COVID-19, and patients with ≥90% were considered moderate COVID-19. Patient medical records and the electronic patient data monitoring system were examined retrospectively. Analyses were performed using the SPSS statistical software. A p-value <0.05 was considered significant. RESULTS The patients’ mean age was 64,32 ± 16,07 years. According to oxygen saturation, 81 patients had moderate and 134 had severe COVID-19. Our findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality. While mortality was 8.4 times higher in patients who had oxygen saturation under 90 % at hospital admission, 1 unit increase in MPV increased mortality 1.76 times. CONCLUSION In addition to the lung capacity of patients, the mean platelet volume may be used as an auxiliary test in predicting the mortality in COVID-19 patients.

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A case of thrombocytopenia associated with the use of hydroxychloroquine following open heart surgery

Cited by 14 publications

References 9 publications

Identifying side effects of commonly used drugs in the treatment of Covid 19

Identifying side effects of commonly used drugs in the treatment of Covid 19

Identifying Side Effects of Some Drugs Used in Covid-19 Treatment

Effect of COVID-19 on platelet count and its indices

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