2012
DOI: 10.2147/ijgm.s30271
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A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis

Abstract: Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cel… Show more

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Cited by 6 publications
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“…If there is a gene mutation existing congenitally leading to absent or severely deficient ADAMTS13 activity, it is called Upshaw-Shulman syndrome. Autoantibodies against ADAMTS13 leading to its decreased activity are called acquired TTP (2). PEX is the first-line treatment and is effective in most of the cases.…”
Section: Discussionmentioning
confidence: 99%
“…If there is a gene mutation existing congenitally leading to absent or severely deficient ADAMTS13 activity, it is called Upshaw-Shulman syndrome. Autoantibodies against ADAMTS13 leading to its decreased activity are called acquired TTP (2). PEX is the first-line treatment and is effective in most of the cases.…”
Section: Discussionmentioning
confidence: 99%