A case of Trypanosoma congolense savannah type infection and its management in a dog

Kimeli, Peter; Kipyegon, A N; Mwangi, Willy E.; Mande, John D.

doi:10.5455/javar.2014.a33

Cited by 5 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like our patient, dogs from Germany [19] and the Netherlands [14] were presented because of ophthalmologic symptoms, but the causative agent was T. evansi and not T. congolense as in the current case. Other case reports describe T. congolense infections in dogs brought from South Africa to the United Kingdom [17] and from Senegal to France [18][20], as well as one case in Kenya [25], but these dogs did not display ophthalmologic signs. Nevertheless, trypanosomosis must be on the differential list for uveitis even in Europe.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type

Leschnik

Silbermayr

Guija

et al. 2021

Tierarztl Prax Ausg K Kleintiere Heimtiere

View full text Add to dashboard Cite

Canine African Trypanosomosis (CAT) is a rarely described disease with frequently lethal outcome. A 5-year-old female mongrel dog weighing 22 kg was presented in Austria due to unilateral uveitis, pancytopenia, and anorexia 4 months after return from a trip through Western Africa. Trypanosoma spp. flagellates were detected in a blood smear and identified as Trypanosoma congolense forest type by PCR. Initial treatment with imidocarb and miltefosine led to clinical improvement but only isometamidium chloride hydrochloride applied intramuscularly led to complete eradication of the pathogen from the dog’s blood 4 months later.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type

Leschnik

Silbermayr

Guija

et al. 2021

Tierarztl Prax Ausg K Kleintiere Heimtiere

View full text Add to dashboard Cite

show abstract

“…Canine African trypanosomosis (CAT) is an important disease of dogs in sub-Sahara African countries (Matete, 2003;Kimeli et al, 2014;Lisulo et al, 2014). In Eastern Nigeria, CAT is responsible for heavy morbidity and mortality of dogs (Omamegbe et al, 1984;Umeakuana et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Molecular identification of trypanosoma species infecting dogs in nigeria by analysis of partial internal transcribed spacer-1 of RRNA gene

Umeakuana¹,

Adepoju²,

Takeet³

et al. 2023

Nig. Vet. J.

View full text Add to dashboard Cite

Trypanosomosis is becoming a major health challenge to dogs in the sub-Sahara Africa including Nigeria, but minimal reports are available on the molecular characteristic of trypanosomes infecting dogs in Nigeria. We characterized trypanosomes detected in naturally infected dogs by PCR and sequences analysis of the partial region of the trypanosomes internal transcribed spacer-1of ribosomal RNA (ITS1 rRNA). Animals presented to the University of Nigeria Veterinary Teaching Hospital (UNVTH) in Nsukka, Nigeria for examination and treatment were sampled for laboratory tests. DNA was extracted from 21 blood samples obtained from dogs that were confirmed positive for trypanosome infection by microscopy. ITS-1 was PCR amplified and sequenced bi-directionally. Sixteen samples have good bands, though one of them had unreadable sequence. Analyses of the sequence data by BLAST search on NCBI identified T. congolense, T. brucei gambiense, and T. evansi in 4.8, 4.8, and 91.4%, respectively, from the analysed samples from the infected dogs. Although the top BLAST hits for T. brucei group were due to T. evansi and T. b. gambiense, there is not enough discriminatory power in ITS-1 to distinguish subspecies. The aligned sequences of the trypanozoon were less polymorphic. Phylogenetic trees inferred by unweighted pair group method with arithmetic mean (UPGMA) algorithms separated trypanozoon group from the T. congolense into two distinct clades. In conclusion, this study suggests that the trypanozoon group of trypanosomes cause more canine trypanosomosis in the study area and suggests inclusion of dogs in strategic planning for control and eradication of trypanosomosis in sub-Sahara African countries.

show abstract

Capillary refill time, bleeding time, clotting time, erythrocyte sedimentation rate and prothrombin time in natural cases of canine Trypanosoma congolense infection

Obiorah

Ugochukwu

2016

Comp Clin Pathol

View full text Add to dashboard Cite

A case of Trypanosoma congolense savannah type infection and its management in a dog

Cited by 5 publications

References 13 publications

Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type

Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type

Molecular identification of trypanosoma species infecting dogs in nigeria by analysis of partial internal transcribed spacer-1 of RRNA gene

Capillary refill time, bleeding time, clotting time, erythrocyte sedimentation rate and prothrombin time in natural cases of canine Trypanosoma congolense infection

Contact Info

Product

Resources

About