A case of twin chimerism.

Angela, E; Robinson, E A; North, Daniel

doi:10.1136/jmg.13.6.528

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…Most reports of chimerism and some reports of mosaicism involve individuals with sex mismatched cell lines, often described as hermaphrodites [Giltay et al, 1998; Strain et al, 1998]. Prior to the availability of molecular testing, human blood chimerism was recognized in individuals with more than one blood type [Angela et al, 1976; Hosoi et al, 1977]. These individuals are generally non‐identical twins who shared an in‐utero blood supply.…”

Section: Introductionmentioning

confidence: 99%

A clinical report of a patient with two abnormal cell lines: 46,XX,del(21)(q22.1) and 47,XX,+3

Quigley

Sailus²,

Kaiser‐Rogers

et al. 2004

American J of Med Genetics Pt A

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Mosaicism for two chromosomally abnormal cell lines in the absence of a normal cell line is exceedingly rare. We report a patient with developmental and growth delay, mild dysmorphic features, a history of hypertension and hepatoblastoma who was found to be mosaic for two chromosomally abnormal cell lines. The cell lines, one containing a terminally deleted chromosome 21, the other trisomy 3, were found in her blood. Fibroblasts and hepatoblastoma tumor cells revealed only the presence of the deleted 21 cell line. Microsatellite marker analysis suggests a mosaic rather than chimeric etiology for the cell lines. This case is exceptional in that the presence of either of these two cell lines alone is uncommon; finding both of these cell lines in an individual appears to be unique.

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Section: Introductionmentioning

confidence: 99%

A clinical report of a patient with two abnormal cell lines: 46,XX,del(21)(q22.1) and 47,XX,+3

Quigley

Sailus²,

Kaiser‐Rogers

et al. 2004

American J of Med Genetics Pt A

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“…Several mechanisms for the development of whole body chimerism have been proposed including postzygotic fusion of two embryos (tetragametic chimerism), fertilization of a parthogenetic oocyte or an oocyte and its polar body by two sperm, and postzygotic diploidization of a triploid zygote 1,2 . Partial chimerism limited to hematopoietic lineages can also occur through transplacental exchange of hematopoietic stem cells between twins or between mother and fetus in utero 3,4 . Additionally, a chimeric state is induced by transplantation or transfusion of allogeneic stem cells.…”

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confidence: 99%

Dispermic chimerism identified during HLA typing for stem cell transplantation

Draper¹,

Conley²,

Smith³

et al. 2008

Transfusion

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This case represents dispermic chimerism, with one maternal and two paternal haplotypes variably distributed throughout body tissues in a phenotypically normal man without abnormalities in blood typing. The presence of additional alleles that may have been undetected or dismissed by serologic typing should be carefully investigated and verified by molecular techniques. Molecular HLA typing may increase the accurate identification of phenotypically normal chimeras and aid in selecting proper donors for transplantation to reduce graft-versus-host disease and transplant rejection in these patients.

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“…Chimerism can be divided into distinct classes: (A) Partial hematopoietic chimerism can be found in dizygotic twins where hematopoietic cells have been exchanged in a context of twin‐twin transfusion over vascular anastomoses between the two dichorionic placentas 3,4 . Also after the transplantation of allogenic marrow or hematopoietic progenitor cells, a so‐called mixed or complete hemopoietic chimerism can result in the patient’s blood 5,6 .…”

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confidence: 99%

Dispermic chimerism identified during blood group determination and HLA typing

et al. 2006

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AB0 blood group genotyping showed three ABO blood group alleles (0(1), A(2) and B) in the DNA-samples of the blood-donor. The evidence of chimerism was supported by the detection of three alleles for the HLA-A and HLA-DRB1 loci. Microsatellite analysis with ten markers revealed three alleles for loci D7S821 and D19S412. All studies carried out, the third allele was always of paternal origin. CONCLISION: The results suggested a case of a human dispermic chimerism. Our proposed explanation for the development of chimerism in the reported case is the fertilization of an oocyte and the corresponding second polar body by two different sperms.

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A case of twin chimerism.

Cited by 14 publications

References 7 publications

A clinical report of a patient with two abnormal cell lines: 46,XX,del(21)(q22.1) and 47,XX,+3

A clinical report of a patient with two abnormal cell lines: 46,XX,del(21)(q22.1) and 47,XX,+3

Dispermic chimerism identified during HLA typing for stem cell transplantation

Dispermic chimerism identified during blood group determination and HLA typing

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