A Case of Unilateral Otologic Symptoms as Initial Manifestations of Granulomatosis With Polyangiitis

Batinović, Franko; Martinić, Marina Krnić; Durdov, Merica Glavina; Sunara, Davor

doi:10.7874/jao.2022.00311

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Otological symptoms may include tinnitus, dizziness, and fullness in the ears. Ear involvement may occur during the course of the disease, but it should be noted that hearing loss may be the initial symptom of GPA [17,45,46]. The study by Bakthavachalam et al suggests that GPA should be considered if hearing loss is permanent or acute [39].…”

Section: Discussionmentioning

confidence: 99%

Audiological Manifestations in Patients with Granulomatosis with Polyangiitis

Vainutienė,

Ivaška,

Dadonienė

et al. 2024

Medicina

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Background and Objectives: Granulomatosis with Polyangiitis (GPA) is a rare, autoimmune, multisystemic disease characterized by vasculitis and necrotizing granuloma that commonly affects the upper and lower respiratory tract and kidneys. Audiovestibular dysfunction in GPA diseases may have different clinical presentations. The aim of the present study was to evaluate hearing function in patients with GPA and to compare the results with a healthy control group. Materials and Methods: A total of 34 individuals participated in the study. The GPA group consisted of 14 participants, and the control group was composed of 20 healthy participants with no signs or symptoms of ear disease. The ages ranged from 18 to 65 years old, with a mean age of 43.8 years. The participants underwent a complete audiological evaluation using otoscopy, impedance audiometry, pure tone audiometry, speech audiometry—evaluation of speech thresholds, and speech recognition in quiet. Both ears were tested. All of the participants of the study were native Lithuanian speakers. Data were statistically analyzed using the Statistical Analysis System software SAS® Studio 3.8. A p value < 0.05 was regarded as statistically significant. Results: 92.85% of patients from the GPA group reported hearing-related symptoms: hearing loss, tinnitus, and fullness in the ears. The arithmetic means of all hearing thresholds at frequencies from 125 Hz to 8000 Hz were significantly higher in the GPA group. The results revealed statistically significant differences between the two groups in the Speech Detection Threshold, Speech Recognition Threshold, Speech Discomfort level, and Word Recognition Scores. Conclusions: The frequency of hearing loss, the average hearing thresholds, and speech thresholds were higher in GPA patients than in healthy individuals. The most common type of hearing loss was sensorineural. Audiological assessments should be considered during the routine evaluation of patients with GPA disease to prevent hearing-related disabilities.

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Section: Discussionmentioning

confidence: 99%

Audiological Manifestations in Patients with Granulomatosis with Polyangiitis

Vainutienė,

Ivaška,

Dadonienė

et al. 2024

Medicina

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“…Also, there is also no difference in incidence between the right and left sides of the face [3,5,6]. Acute facial palsy can be attributed to a various underlying medical condition such as infections, cholesteatoma, trauma, acoustic tumors, malignancies, autoimmune disorders, pregnancy, iatrogenic injuries, and congenital abnormalities [5,[7][8][9]. The most common type of acute facial palsy is idiopathic Bell's palsy (BP).…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus and Acute Facial Palsy: A Nationwide Population-Based Study

Seo,

Ryu,

Lee

et al. 2023

Neuroepidemiology

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Introduction: Acute facial palsy, characterized by sudden hemifacial weakness, significantly impacts an individual’s quality of life. Despite several predisposing factors identified for acute facial palsy, the specific relationship between diabetes mellitus (DM) and acute facial palsy has not been comprehensively explored in recent studies. The aim of the study was to assess the risk of acute facial palsy in patients with DM using a nationwide population sample cohort. Methods: DM cohort and non-DM cohort were built using the Korean National Health Insurance Service-Sample Cohort which represents the entire population of the Republic of Korea from January 2002 to December 2019. The DM cohort comprised 92,872 patients with a record of medication and a diagnosis of DM. Individuals who had facial palsy before the diagnosis of DM were excluded. A comparison cohort comprised 1,012,021 individuals without DM matched sociodemographically in a 1:4 ratio. The incidence of Bell’s palsy (BP) and Ramsay Hunt syndrome (RHS) were evaluated in both cohorts. The risk factors for acute facial palsy were also assessed. Results: Among the 92,868 patients in the DM cohort, the incidence rate (IR) of BP and RHS were 31.42 (confidence interval [CI], 30.24–32.63) and 4.58 per 10,000 person-years (CI, 4.14–5.05), respectively. Among the 371,392 individuals in the non-DM cohort, the IR of BP was 22.11 per 10,000 person-years (CI, 21.62–22.59) and the IR of RHS was 2.85 per 10,000 person-years (CI, 2.68–3.02). IR ratios for BP and RHS were 1.42 (CI, 1.36–1.48) and 1.61 (CI, 1.43–1.80). In multivariate analysis, DM (hazard ratio [HR] 1.428), age (HR 1.008), and high comorbidity score (HR 1.051) were associated with increased risk of BP, and male (HR 0.803) and living in metropolis (HR 0.966) decreased the risk of BP. And DM (HR 1.615), high comorbidity score (HR 1.078), and living in metropolis (HR 1.201) were associated with increased risk for RHS. Conclusion: This study suggests that patients with DM had an increased risk of acute facial palsy including BP and RHS.

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A Case of Unilateral Otologic Symptoms as Initial Manifestations of Granulomatosis With Polyangiitis

Cited by 2 publications

References 11 publications

Audiological Manifestations in Patients with Granulomatosis with Polyangiitis

Audiological Manifestations in Patients with Granulomatosis with Polyangiitis

Diabetes Mellitus and Acute Facial Palsy: A Nationwide Population-Based Study

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