2006
DOI: 10.1038/sj.sc.3101962
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A case of unusual substance abuse causing myeloneuropathy

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Cited by 31 publications
(28 citation statements)
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“…[1][2][3][4][5][6][7][8][9]. The appeal of these reports seems to be that this association, between nitrous oxide exposure and B 12 deficiency myelopathy, comes as a novel and surprising fact to many physicians.…”
Section: Introductionmentioning
confidence: 95%
“…[1][2][3][4][5][6][7][8][9]. The appeal of these reports seems to be that this association, between nitrous oxide exposure and B 12 deficiency myelopathy, comes as a novel and surprising fact to many physicians.…”
Section: Introductionmentioning
confidence: 95%
“…In these cases vitamin B12 deficiencies were due to pernicious anemia [14][15][16], intestinal malabsorption [17], poor diet [18][19][20], drugs [21], and nitrous oxide abuse [22]. Arterial and venous thrombotic events have been demonstrated including recurrent thrombosis [16,20] and unexpected sites of thromboses such as sinus venous thrombosis [14,17,20], spleen and kidney infarction [14], or portal venous thrombosis [23].…”
Section: Introductionmentioning
confidence: 98%
“…T2-weighted MRI images of the spinal cords of patients with chronic nitrous oxideinduced myelopathy have shown increased uptake in the posterior columns (3)(4)(5)(6). Our patient had normal brain and cervical spine MRIs; however, he demonstrated signs and symptoms of a marked myeloneuropathy in the setting of short-term, high-dose nitrous oxide abuse.…”
Section: Discussionmentioning
confidence: 71%
“…These reports describe months of constant nitrous oxide abuse before the onset of neurologic symptoms (3,4,6). Goldfrank's Toxicologic Emergencies also describes the neurologic changes associated with nitrous oxide as occurring only after months of frequent exposure (7).…”
Section: Discussionmentioning
confidence: 97%
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