A case of vulvitis circumscripta plasmacellularis positive for herpes simplex type II antigen

Kuniyuki, Shuichi; Asada, Tetsuhiro; Yasumoto, Ryoma

doi:10.1046/j.1365-2230.1998.00292.x

Cited by 18 publications

(23 citation statements)

References 5 publications

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“…White et al 9 . suggested that warmth, constant rubbing and chronic infection (herpes simplex virus 6,10 or Mycobacterium smegmatis 11 ) can predispose to the onset of the disease.…”

Section: Discussionmentioning

confidence: 99%

Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports

Yosipovitch

Chan

et al. 2003

Br J Dermatol

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Vulvitis circumscripta plasmacellularis (VCP) is a rare but well-described entity. It is notorious for its recalcitrant nature to various modalities of treatment. Intralesional interferon-alpha showed some promise, with complete resolution, but is coupled with the side-effect of myelosuppression. Topical imiquimod is a novel immune response modifier with the ability to induce the production of interferon-alpha. In this paper, we report two cases of VCP whose lesions were resistant to antibiotics, topical and oral corticosteroids, but resolved after a treatment trial with imiquimod.

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“…White et al 9 . suggested that warmth, constant rubbing and chronic infection (herpes simplex virus 6,10 or Mycobacterium smegmatis 11 ) can predispose to the onset of the disease.…”

Section: Discussionmentioning

confidence: 99%

Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports

Yosipovitch

Chan

et al. 2003

Br J Dermatol

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“…The withdrawal of gluten from the diet of 6 of them was followed by a partial or complete new growth of scalp and other body hair in 4, whereas 2 patients did not respond and 2 others refused the GFD. Two other reports described the association between AA and CD in 4 cases and a GFD resolved completely the hair loss in 2 of them; in these 2 patients, the areas of AA displayed an initial growth of hair after only 6 months of diet [7, 8]. …”

Section: Discussionmentioning

confidence: 99%

“…Recently, an association between AA and coeliac disease (CD) has been reported in two different series of about 250 patients each. Five cases were detected in these series, while 7 other patients with the same association have been described as case reports [5, 6, 7, 8]. In 6 of these patients, a gluten-free diet (GFD) was followed by a partial or complete regrowth of hair [5, 6, 7].…”

Section: Introductionmentioning

confidence: 98%

Alopecia areata and Coeliac Disease: No Effect of a Gluten-Free Diet on Hair Growth

Bardella¹,

Marino²,

Barbareschi

et al. 2000

Dermatology

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Background: An association between alopecia areata (AA) and coeliac disease has recently been reported. Aim: The aim of this paper was to evaluate the possible effect of a gluten-free diet (GFD) on the new growth of hair in 5 alopecic patients with CD. Methods: CD was diagnosed in 5 patients with AA (universalis in 3 cases and patchy in 2 cases). The diagnosis of CD was based on serological and histological standard criteria. Results: In all patients the GFD resolved CD clinically, serologically and histologically but had no effect on the course of alopecia. Conclusion: AA and CD, when associated, present different responses to a GFD and have an independent course.

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“…2,4 The etiology and pathogenesis of VCP remain unclear, but predisposing factors, such as infection, poor hygiene, heat, and constant friction have been suggested. 5,6 In our patient's case, due to the pruritic characteristic (which may trigger friction) of lichen sclerosus, the cause of VCP may have been lichen sclerosus.…”

Section: Discussionmentioning

confidence: 73%

Vulvitis circumscripta plasmacellularis in pre-existing lichen sclerosus

Kim

Park

et al. 2014

Dermatologica Sinica

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a b s t r a c tVulvitis circumscripta plasmacellularis (VCP) is a rare, benign vulvar disorder that presents with erythematous patches and erosions. Patients with VCP usually experience vulvodynia, pruritus, or dyspareunia, which may cause severe discomfort. A 72-year-old woman presented with 10 years of vulvar pruritus and whitish patches on the labia minora and majora. A biopsy was performed on the labia minora and lichen sclerosus was diagnosed. Her condition improved after treatment with a topical steroid. After 5 months, however, her symptoms reappeared with aggravated skin lesions. A rebiopsy was performed and VCP was diagnosed. There have only been two reported cases of concurrence of VCP with lichen sclerosus. We herein report an unusual case of VCP in pre-existing lichen sclerosus. IntroductionVulvitis circumscripta plasmacellularis (VCP) was first described by Garnier 1 in 1954. It is a relatively rare chronic inflammatory disease. It is clinically and histopathologically similar to balanitis circumscripta plasmacellularis in males. Clinical symptoms of VCP are vulvodynia, pruritus, or dyspareunia, but VCP may be asymptomatic. 2 Only two cases have been reported on concurrent VCP and vulvar lichen sclerosus. 2,3 In this report, we describe an unusual case of VCP in pre-existing lichen sclerosus. Case reportA 72-year-old woman presented with 10 years of vulvar pruritus. She had localized whitish patches on the labia minora and majora ( Figure 1A). Her medical history included hypertension for 1 year. Laboratory test results were within normal limits. A biopsy was performed on the labia minora, including the majora, the results of which revealed pronounced edema and homogenization of collagen in the upper dermis. Hyperkeratosis and follicular plugging in the epidermis and inflammatory infiltrate in the middermis were observed (Figure 2). Lichen sclerosus was diagnosed, and the patient was treated with a topical potent corticosteroid (clobetasol-17-propionate) for 2 weeks. Her condition improved, but her symptoms were aggravated after 5 months. She presented with severe pruritus and pain in the vulvar area. A physical examination revealed localized whitish to erythematous eroded patches on the labia minora ( Figure 1B). A rebiopsy on the eroded patches of the labia minora was performed to rule out squamous cell carcinoma. The biopsy specimen showed epidermal thinning, absence of the stratum corneum, irregular acanthosis, and spongiosis in the epidermis. A dense dermal lichenoid infiltrate with many plasma cells and lymphocytes was observed (Figure 3). Results of an immunohistochemical analysis revealed that plasma cells were polyclonal for kappa and lambda light chains, and syphilis testing with venereal disease research laboratory was negative. Based on the results of the biopsy, VCP was diagnosed. After treatment with a systemic and topical corticosteroid, the patient's condition temporarily improved; however, her symptoms recurred, and she was advised to apply imiquimod 5% cream two to three times a wee...

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A case of vulvitis circumscripta plasmacellularis positive for herpes simplex type II antigen

Cited by 18 publications

References 5 publications

Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports

Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports

Alopecia areata and Coeliac Disease: No Effect of a Gluten-Free Diet on Hair Growth

Vulvitis circumscripta plasmacellularis in pre-existing lichen sclerosus

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