A case of Warthin's tumour with coexistent Hodgkin's disease

Badve, Sunil; Evans, G.; Mady, S.; Coppen, M J; Sloane, J P

doi:10.1111/j.1365-2559.1993.tb00121.x

Cited by 29 publications

(21 citation statements)

References 4 publications

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“…The possibility for the lymphoma to originate in the lymphoid tissue of WT is supported by several reports indicating that WT-associated lymphoma may remain a localized disease for long periods of time (2,5). On the other hand, the major studies indicate that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma (3,4,7). In the advanced stages, the distinction between primary and secondary lymphomas may be impossible and unnecessary.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant lymphoma involving WT is uncommon and is almost single-case reports with 28 cases, mostly are non-Hodgkin B-cell lymphomas with a prevalence of follicular lymphomas (2)(3)(4)(5)(6)(7)(8). The co-existence of WT and classical Hodgkin lymphoma (CHL) is extremely rare with only 3 reported cases, which all occurred in the parotid gland (3,4,7). Herin we describe a case of mixed-cellularity CHL (MCCHL) that primarily presented as part of the ectopic WT in a lymph node of the neck.…”

Section: Introductionmentioning

confidence: 99%

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Classical Hodgkin lymphoma arising from heterotopic Warthin's tumor in the cervical lymph node: A case report

Zhu

2018

Oncol Lett

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Abstract. Heterotopic Warthin's tumor (WT) arising from the cervical lymph nodes is uncommon and WT presenting concomitantly with classical Hodgkin's lymphoma has only been previously reported three times in English literature. The current study presents an unusual case of classical Hodgkin lymphoma (CHL) involving the heterotopic WT in a 59-year-old male. Histopathologic examination revealied a WT with extensive expansion of mixed-cellularity CHL in a lymph node in the right of the neck. Clinical staging was determined as stage IA disease. The patient received four courses of chemotherapy and local consolidative radiotherapy, no evidence of disseminated lymphoma was observed over the 6-month follow-up. To the best of our knowledge, this is the first well documented collision tumor between CHL and heterotopic WT of the cervical lymph nodes. The present case also expands the anatomical site of malignant lymphomas associated with WT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Classical Hodgkin lymphoma arising from heterotopic Warthin's tumor in the cervical lymph node: A case report

Zhu

2018

Oncol Lett

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“…Lymphomas associated with WT are extremely rare. A review of the English literature provided 23 cases of WT related to malignant lymphoma (Table 1) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Considering only the cases with existing data, this association occurred in eighteen males (81,8%) and four females (18,2%), with a mean age of 67 years.…”

Section: Discussionmentioning

confidence: 99%

“…Uncommonly, the lymphoid stroma in WT is infiltrated by malignant lymphoma. To date, there are 23 reported cases in the English literature of lymphomas associated with WT [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Most cases are B cell lymphomas-namely follicular lymphoma [2, 4-8, 11, 12, 14, 15], small lymphocytic lymphoma [10,18] and diffuse large B-cell lymphoma [8,19]-and are usually associated with generalized disease, which is either present at the time of diagnosis or develops subsequently.…”

Section: Introductionmentioning

confidence: 99%

T cell lymphoblastic lymphoma in parotidectomy for Warthin’s tumor: case report and review of the literature

et al. 2009

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Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland. The parotidectomy specimen showed a WT with extensive replacement of the lymphoid stroma by T-LBL, but preservation of the oncocytic epithelium. Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease. The patient received combination chemotherapy treatment but responded poorly, and died three months after diagnosis. To our knowledge, this is the first case report of T-LBL involving WT. The present study indicates that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma. It highlights the importance of careful examination of WT's lymphoid stroma for the possible presence of any coexistent malignancy.

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“…The most common lymphoma in this site is follicular lymphoma (76,77). Hodgkin's lymphoma is occasionally seen (78).…”

Section: Salivary Gland Lymphoid Hyperplasia and Lymphomamentioning

confidence: 99%

Lymphoid Lesions of the Head and Neck: A Model of Lymphocyte Homing and Lymphomagenesis

Jaffe

2002

Modern Pathology

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A case of Warthin's tumour with coexistent Hodgkin's disease

Cited by 29 publications

References 4 publications

Classical Hodgkin lymphoma arising from heterotopic Warthin's tumor in the cervical lymph node: A case report

Classical Hodgkin lymphoma arising from heterotopic Warthin's tumor in the cervical lymph node: A case report

T cell lymphoblastic lymphoma in parotidectomy for Warthin’s tumor: case report and review of the literature

Lymphoid Lesions of the Head and Neck: A Model of Lymphocyte Homing and Lymphomagenesis

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