A Case of Weak Mineralocorticoid-Producing Benign Adrenal Tumor

Matsumoto, Fumi; Kono, Hiroshi; Kokado, Yukito; Iida, Shinji

doi:10.1159/000282521

Cited by 1 publication

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Matsumoto et al. ( 26 ) reported a case of weak mineralocorticoid-producing benign adrenal tumor with a doubling of serum DOC levels. The authors hypothesized that another mineralocorticoid intermediate different from DOC, 18-hydroxy-deoxycorticosterone (18-OH-DOC, a hydroxylated metabolite of DOC), that was above the normal value, might be responsible for the hypertensive state of that patient ( 26 ).…”

Section: Discussionmentioning

confidence: 88%

“…( 26 ) reported a case of weak mineralocorticoid-producing benign adrenal tumor with a doubling of serum DOC levels. The authors hypothesized that another mineralocorticoid intermediate different from DOC, 18-hydroxy-deoxycorticosterone (18-OH-DOC, a hydroxylated metabolite of DOC), that was above the normal value, might be responsible for the hypertensive state of that patient ( 26 ). In addition to 18-OH-DOC, other mineralocorticoid precursor related to DOC, such as 19-Nor-DOC, can cause overt hypertension ( 51 ), especially in patients with slightly elevated DOC levels.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Background and Objectives11-deoxycorticosterone overproduction due to an adrenal tumor or hyperplasia is a very rare cause of mineralocorticoid-induced hypertension. The objective is to provide the most relevant clinical features that clinicians dealing with patients presenting with the hallmarks of hypertension due to 11-deoxycorticosterone-producing adrenal lesions should be aware of.Design and MethodsWe report the case of a patient with an 11-deoxycorticosterone-producing adrenal lesion and provide a systematic review of all published cases (PubMed, Web of Science and EMBASE) between 1965 and 2021.ResultsWe identified 46 cases (including ours). Most cases (31, 67%) affected women with a mean age of 42.9 ± 15.2 years and presented with high blood pressure and hypokalemia (average of 2.68 ± 0.62 mmol/L). Median (interquartile range) time from onset of first suggestive symptoms to diagnosis was 24 (55) months. Aldosterone levels were low or in the reference range in 98% of the cases when available. 11-deoxycorticosterone levels were a median of 12.5 (18.9) times above the upper limit of the normal reference range reported in each article and overproduction of more than one hormone was seen in 31 (67%). Carcinoma was the most common histological type (21, 45.7%). Median tumor size was 61.5 (60) mm. Malignant lesions were larger, had higher 11-deoxycorticosterone levels and shorter time of evolution at diagnosis compared to benign lesions.Conclusions11-deoxycorticosterone-producing adrenal lesions are very rare, affecting mostly middle-aged women with a primary aldosteronism-like clinical presentation and carcinoma is the most frequent histological diagnosis. Measuring 11-deoxycorticosterone levels, when low aldosterone levels or in the lower limit of the reference range are present in hypertensive patients, is advisable.Systematic Review RegistrationOpen Science Framework, 10.17605/OSF.IO/NR7UV.

show abstract

Section: Discussionmentioning

confidence: 88%