A case of Wunderlich syndrome

Deschasse, Guillaume; Damier, É.; Steenpass, V.; Garnier, V.; Couturier, Pascal; Gavazzi, G.

doi:10.1016/j.eurger.2011.11.009

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Spontaneous nontraumatic renal hemorrhage was rst documented in the literature by Bonet in 1700 as a rare disease, although it was again reported as Wünderlich syndrome by a German doctor in 1856. [1][2][3][4][5][6][7][8][9][10][11][12][13] Spontaneous bilateral renal hemorrhage is extremely rare because it is unlikely to occur in the absence of anticoagulant or antiplatelet intake when it occurred consecutively not simultaneously. 14 In our case, the rst event of the renal hemorrhage occurred when the patient took clopidogrel (oral antiplatelet) daily, and the second event of renal hemorrhage occurred only 15 days after the rst hospital discharge.…”

Section: Discussionmentioning

confidence: 99%

Nontraumatic spontaneous bilateral renal hemorrhages (Wünderlich syndrome) with chronic infection of Chlamydia pneumoniae: A case report

Matsumoto

Tanaka

Terayama

et al. 2022

Preprint

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Background: Nontraumatic spontaneous renal hemorrhage is caused by tumor such as renal cell carcinoma or angiomyolipoma in most cases. Vasculitis including periarteritis nodosa or antineutrophil cytoplasmic antibody (ANCA)-mediated vasculitis may also be the next underlying background. Herein, we report the first case of nontraumatic spontaneous bilateral renal hemorrhage combined with chronic infection of Chlamydia pneumoniae.Case presentation: The patient serially suffered from left and right back pain within 78 days due to bilateral spontaneous renal hemorrhages. Transcatheter arterial embolization was successfully performed twice to treat serial spontaneous bilateral renal hemorrhages. The serological examination apparently revealed his chronic infection of Chlamydia pneumoniae and a slight elevation of anti-deoxy nucleotide antibodies. Furthermore, computed tomography (CT) angiogram and 67galium citrate scintigram also suggested underlining severe arteriosclerosis without severe inflammation in bilateral kidneys. Chronic infection of Chlamydia pneumoniae and underlying autoimmune vasculitis may pull a trigger of bilateral spontaneous renal hemorrhages although the real mechanisms remain unknown. Conclusions: In conclusion, we reported an extremely rare case of nontraumatic spontaneous bilateral renal hemorrhage of unknown etiology. Severe atherosclerosis caused by chronic infection due to Chlamydia pneumoniae may predispose to the vascular vulnerability of the bilateral renal arteries in close association with hypertension, oral intake of antiplatelets, and underlying autoimmune vasculitis.

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Section: Discussionmentioning

confidence: 99%

Nontraumatic spontaneous bilateral renal hemorrhages (Wünderlich syndrome) with chronic infection of Chlamydia pneumoniae: A case report

Matsumoto

Tanaka

Terayama

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Wunderlich syndrome is a spontaneous, nontraumatic, but occasionally life-threatening kidney bleeding. 1 A meta-analysis of Wunderlich syndrome showed that nephrectomy remains the most common intervention because 61 per cent of patients present with a benign or malignant neoplasm. 2 Causes of Wunderlich syndrome, besides tumor or vascular diseases, are very rarely reported.…”

Section: Preoperative Embolization Facilitates the Treatment Of Wunderlich Syndromementioning

confidence: 99%