A case presenting with the possible relationship between myeloperoxidase–antineutrophil cytoplasmic antibody-associated glomerulonephritis and membranous changes of the glomerular basement membrane

Uyama, Satoko; Ohashi, Naro; Iwakura, Takamasa; Ono, Masafumi; Fujikura, Tomoyuki; Sakao, Yukitoshi; Yasuda, Hideo; Kato, Akihiko; Fujigaki, Yoshihide

doi:10.1007/s13730-012-0039-9

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…However, all of the conventional renal pathology findings in our patient could be explained by ANCA-associated glomerulonephritis. In another case, we observed the spontaneous resolution of MPO-ANCA levels without immune therapy ( 17 ). Therefore, it is possible that MPO-ANCA levels could fluctuate within a low range in the present case, leading to spontaneous resolution at the time of measurement.…”

Section: Discussionmentioning

confidence: 94%

Slowly Progressive ANCA-associated Glomerulonephritis with Strong Mesangial MPO Deposits Following a Diagnosis of Interstitial Lung Disease

Anzai,

Suzuki,

Ueno

et al. 2024

Intern. Med.

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An elderly woman showed positive conversion of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCAs) following the diagnosis of interstitial lung disease (ILD) and glomerular hematuria and subsequently experienced slowly progressive glomerulonephritis. A kidney biopsy revealed chronic damage and necrotizing crescentic glomerulonephritis with mesangial MPO deposits. After corticosteroid treatment, the patient's urinalysis results and MPO-ANCA titers almost normalized and her renal function stabilized. This case is similar to recently reported cases of slowly progressive ANCA-associated glomerulonephritis. ILD likely triggered the production of MPO-ANCAs, and the accumulation of MPO deposits in the glomeruli may have contributed to the progression of her renal disease.

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Section: Discussionmentioning

confidence: 94%

Slowly Progressive ANCA-associated Glomerulonephritis with Strong Mesangial MPO Deposits Following a Diagnosis of Interstitial Lung Disease

Anzai,

Suzuki,

Ueno

et al. 2024

Intern. Med.

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“…Previous primary therapy was glucocorticoid and cyclophosphamide (CTX). Although the renal function was steady and no acute histological change found in admission, a rapid exacerbation is possible (14). For this reason, early treatment is of paramount importance for these patients.…”

Section: Discussionmentioning

confidence: 98%

Coexistence of antineutrophil cytoplasmic antibody-associated vasculitis and membranous nephropathy: a case report

Gao¹,

Wang²,

Dong³

et al. 2020

Ann Palliat Med

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and membranous nephropathy (MN) are two types of diseases that can both involve kidneys. In recent years, there are some reports about the concurrence of these two diseases. However, the precise mechanism, clinical course, and optimal treatment of patients with this unusual combination of renal diseases are little known.Previously reported cases of MN combined with AAV presented characteristics of both MN and crescentic glomerulonephritis, manifesting rapid disease progression and poor prognosis. Diagnosis and treatment are essential and challenging. Here, we report a case of AAV and MN in a 62 years old man, who was admitted to hospital due to edema, low-grade fever, and cough. The patient showed a different pathological feature from previous cases, with no crescent formation. By analyzing the diagnoses and potential pathogenesis, we considered MN was secondary to the present AAV and suspected the existence of other alternative mechanisms. Also, we applied a new therapy, glucocorticoid with mizoribine. After one-year follow-up, this treatment is feasible, safe, and leads to a clinical improvement for AAV combined with MN. In this case, two diseases overlapped, and the laboratory analysis and pathology are both required to ensure diagnostic accuracy. The principal aim of this case report is to highlight the diagnostic challenge and distinct treatment in the simultaneous occurrence of AAV combined with MN.

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“… 10 Although ANCA GN is characterized by pauci-immune crescentic GN, 1 ANCA GN with MN cases are rare. 2 , 4 , 11 Particularly, several MPO-ANCA GN with MN cases exist, 5 , 6 , 7 , 12 , 13 , 14 , 15 , 16 , 17 some of which are positive for MPO and IgG along the GBM. 5 , 18 , 19 Hanamura et al.…”

Section: Discussionmentioning

confidence: 99%

Myeloperoxidase-Associated Membranous Nephropathy in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis

Tominaga,

Toda,

Takeuchi

et al. 2024

Kidney International Reports

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A case presenting with the possible relationship between myeloperoxidase–antineutrophil cytoplasmic antibody-associated glomerulonephritis and membranous changes of the glomerular basement membrane

Abstract: A 72-year

Cited by 4 publications

References 16 publications

Slowly Progressive ANCA-associated Glomerulonephritis with Strong Mesangial MPO Deposits Following a Diagnosis of Interstitial Lung Disease

Slowly Progressive ANCA-associated Glomerulonephritis with Strong Mesangial MPO Deposits Following a Diagnosis of Interstitial Lung Disease

Coexistence of antineutrophil cytoplasmic antibody-associated vasculitis and membranous nephropathy: a case report

Myeloperoxidase-Associated Membranous Nephropathy in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis

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