A Case Report and Review of Early Symptomatic Congenital Syphilis Clinical Variations

Kučinskienė, Vesta; Russetti, Laura; Stonienė, Dalia; Vitkauskienė, Astra; Valiukevičienė, Skaidra; Tamelienė, Rasa

doi:10.1177/0009922816638666

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Congenital syphilis usually results from lack of prenatal care and adequate treatment for syphilis before or during pregnancy. 3 The transmission rates are highest in primary and secondary stages of maternal syphilis infection (40%–90%). 4 Untreated intrauterine syphilis infections cause abortion, stillbirth, or preterm delivery in 30%–40% of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…4 Untreated intrauterine syphilis infections cause abortion, stillbirth, or preterm delivery in 30%–40% of the cases. 3 Up to two-thirds of patients with congenital syphilis are asymptomatic after birth. 3 When symptoms appear, the disease may manifest in 2 categories: early congenital syphilis and late congenital syphilis.…”

Section: Discussionmentioning

confidence: 99%

“…3 Up to two-thirds of patients with congenital syphilis are asymptomatic after birth. 3 When symptoms appear, the disease may manifest in 2 categories: early congenital syphilis and late congenital syphilis. 1 Early congenital syphilis is usually identified by 3 months of age but could be as late as 2 years of age.…”

Section: Discussionmentioning

confidence: 99%

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Congenital Syphilis and the Prozone Phenomenon: Case Report

Catueno

Tsou

Wang

et al. 2022

Pediatric Infectious Disease Journal

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Slehria et al dogs. In the case of this patient, there were no reported bites or scratch marks from the 2 dogs in the household. It is unclear whether the patient could have been directly licked at some point or her pacifier could have been inadvertently contaminated from the pet's saliva. Additionally, a family member who was licked by the dogs could have been in direct or immediate contact with the patient without adequate hand hygiene.P. multocida remains a rare cause of infantile bacterial meningitis but can be associated with detrimental outcomes. Similar to this patient, seizures have been reported in other cases of neonatal and infantile P. multocida meningitis as well. 4,9 A long-term adverse outcome of the infection is hearing loss, which is seen in up to 20%-30% of patients. 6 Considering the existing data and case reports thus far, care should be taken with infants, especially in and around the neonatal period, with direct and indirect exposures to household pets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Congenital Syphilis and the Prozone Phenomenon: Case Report

Catueno

Tsou

Wang

et al. 2022

Pediatric Infectious Disease Journal

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“…Lab findings include anemia, thrombocytopenia, leukopenia or leukocytosis, and abnormal liver function tests. Neurologic, ophthalmologic, auditory, and pulmonary manifestations that can overlap with autoinflammatory or autoimmune syndromes may also be seen.Typical cutaneous findings include macules and papules than can evolve to a copper color, vesicles or bullae that denude leaving flat crusts, scattered erosions, palmoplantar desquamation, rhagades, condyloma lata, and mucous patches 4. Petechiae (often secondary to thrombocytopenia), violaceous retiform plaques, and diffuse alopecia have also been described in the literature 5,6.…”

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confidence: 99%

Congenital syphilis presenting with granulomatous scalp nodules

Vuong,

Lie,

Ellington

et al. 2023

Pediatric Dermatology

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We describe a case of congenital syphilis in an adopted infant with a unique dermatologic presentation of scalp granulomas, along with lymphadenopathy, anemia, and elevated liver transaminases. To our knowledge, this cutaneous morphology has not been previously reported in the literature. This case highlights the varied clinical presentation of congenital syphilis and the diagnostic challenge it poses for clinicians, especially in the context of unknown prenatal history/unknown risk factors, or if syphilis is acquired during pregnancy after routine screening is performed. As the incidence of congenital syphilis has more than tripled in recent years, this diagnosis should be considered when a neonate or infant presents with unexplained skin nodules.

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