A case report of a patient with a Leydig cell tumor, poor blood pressure control, and ventricular septal hypertrophy

Qin, Zuoan; Yu, Jiangbiao; Guo, Ning

doi:10.1016/j.ehpc.2020.200463

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous clinical cases and studies have indicated an association between Leydig cell tumors and hypertension. Excessive secretion of androgens can also lead to obesity, cardiovascular complications, metabolic syndrome and type 2 diabetes in postmenopausal women [ 12 ]. In our described clinical case, the patient was diagnosed with obesity and primary hypertension in the same year as virilising symptoms were observed, suggesting a possible association between OH, Leydig cell ovarian tumor and the development of metabolic manifestations.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review

Bužinskienė,

Marčiukaitytė,

Šidlovska

et al. 2023

Medicina

View full text Add to dashboard Cite

Ovarian Leydig cell tumor is a rare type of ovarian steroid cell neoplasms, presenting in only 0.1% of all ovarian tumor cases, and is generally androgen-secreting and unilateral. Although they are often malignant non-spreading tumors, which have excellent prognosis, benign ovarian Leydig cell tumors with low-risk malignancy can be also detected. Ovarian hyperthecosis is a rare non-neoplastic disorder, in most cases bilateral. Ovarian tumors and ovarian hyperthecosis are one of the main causes of hyperandrogenism in postmenopausal women, a condition strongly associated with both hormonal and metabolic changes. Here, we report a 65-year-old patient with complaints of excessive body hairiness and alopecia. The laboratory investigation showed increased levels of serum testosterone and dehydroepiandrosterone sulfate (DHEA-S). Imaging, including transvaginal ultrasound and pelvic MRI revealed the presence of two masses in the ovaries. The patient underwent a laparoscopic bilateral salpingo-oophorectomy due to the ovarian tumors unknown etiology, and histopathological examination revealed a unilateral benign left ovarian Leydig cell tumor with bilateral ovarian stromal hyperplasia and ovarian hyperthecosis. Making differential diagnosis between ovarian tumors and ovarian hyperthecosis is difficult. Bilateral salpingo-oophorectomy is the treatment of choice in postmenopausal women with benign Leydig cell ovarian tumor, as well as ovarian hyperthecosis, as it offers both a cure and diagnostic confirmation.

show abstract

Section: Discussionmentioning

confidence: 99%