A Case Report of a Patient with Turner Syndrome, Multiple Comorbidities, and Pustular Psoriasis: Correlation or Coincidence?

Abstract

Turner syndrome (TS) is one of the most common chromosomal abnormalities. Patients with TS are at an increased risk for the development of metabolic syndrome, hypertension (HTN), diabetes mellitus type II (DM2), hyperlipidemia (HLD), obesity, and cardiovascular disease. The association between psoriasis and the aforementioned conditions including metabolic syndrome, HTN, HLD, obesity, and cardiovascular disease has also been established. Although the mechanism for heightened risk in TS patients is yet to be elucidated, patients suffering from TS and cardiometabolic diseases are likely to be at an even higher risk for developing psoriasis than patients suffering from TS alone. We present a case of a 53-year-old Hispanic woman with a mosaic TS and multiple comorbidities who presented with pustular psoriasis. For this patient, management can be challenging considering her numerous medical comorbidities and the presence of both TS and psoriasis.

Disorders of the eye, ear, skin, and nervous system in women with Turner syndrome –a nationwide cohort study

“…In addition to increased risk of atopic dermatitis and eczema, we report an increased risk of psoriasis. Multiple case reports have linked Turner syndrome with different psoriatic manifestations [37][38][39][40][41][42], although two epidemiological studies were not able to document a correlation [2,14]. We speculate that this might be due to small study populations, since we, in this larger cohort, report a significantly elevated risk of psoriasis.…”

“…We also speculate, that since sensorineural hearing loss advances with age, and since a TS women can act as both HRT non-treated (early life) and later HRT treated, the increased risk might reflect an increased age. Median age in the HRT non-treated group was 30 years old (range 28-31 years) compared with 41 years old (range [40][41][42] in the HRT treated group of TS women. However, further scrutiny of the effect of oestrogens on the inner ear is warranted.…”