A Case Report of a Rare Rh Phenotype: D—

Pour, Maryam Samareh Salavati; Soleimany, Saeed; Ghasemimehr, Narges; Khalilabadi, Roohollah Mirzaee

doi:10.1007/s12288-019-01089-7

Cited by 5 publications

(2 citation statements)

References 10 publications

(13 reference statements)

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“…The implementation of such programs can be considered beneficial steps for the management of rare blood groups. 14 Taken together, this study reported a rare case of RhD -/phenotype that resulted in hemolysis in a one-day-old infant. The transfusion of WRBC obtained from the mother improved the clinical manifestations of anemia and jaundice, which can be a reference for the management of subsequent cases.…”

Section: Neonatal Hemolytic Anemia Due To the Mother's Rare Rhd -/Phe...mentioning

confidence: 51%

Neonatal hemolytic anemia due to the mother's rare RhD^–/– phenotype: A case report

Soleimany,

Shokouhi,

Samare‐Najaf

2024

Pediatric Blood & Cancer

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Section: Neonatal Hemolytic Anemia Due To the Mother's Rare Rhd -/Phe...mentioning

confidence: 51%

Neonatal hemolytic anemia due to the mother's rare RhD^–/– phenotype: A case report

Soleimany,

Shokouhi,

Samare‐Najaf

2024

Pediatric Blood & Cancer

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“…These five Rh antigens are known to evoke alloantibodies following mismatched blood transfusions and are thereby clinically significant. They are encoded by two highly homologous RH genes, that is, RHD (D antigen) and RHCE (C, c, E, and e antigens) located on chromosome 1p36.11 1 . The D antigen is most immunogenic in nature and is the major cause of haemolytic disease of the fetus and newborn (HDFN).…”

Section: Introductionmentioning

confidence: 99%

D‐‐phenotype due to RHD‐RHCE hybrid transcript in a case of severe haemolytic disease of newborn with anti‐Rh 17(Hrₒ) antibodies

Mani

Mishra

Kulkarni

et al. 2021

Transfusion Medicine

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Background D antigen is one among the most immunogenic antigens and is the most common cause of Haemolytic Disease of Fetus and Newborn (HDFN). The D‐phenotype is a rare Rh variant in which none of the RhCE antigens are expressed on the red cell surface. Individuals having D‐phenotype are capable of producing a rare alloantibody named as anti‐Rh17(Hr°) in response to pregnancy or transfusion and has the potential to react with C/c and E/e antigens causing severe haemolytic transfusion reaction (HTR) and haemolytic disease of fetus and newborn (HDFN). Case report We have encountered a case of severe HDFN with an accidental discovery of D‐ phenotype of the mother with anti‐Rh‐17 antibodies. D‐ phenotype has been confirmed with molecular typing along with genotyping of all family members. Conclusion Rare phenotypes like D‐ individuals especially if allo‐immunised are of great concern at times of transfusion requirements. Hence, proper identification of these individuals are important to contribute them to the rare donor pool and to adopt adequate patient blood management strategies.

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The RHCE gene encodes the chicken blood system I

Fulton,

McCarron,

Lund

et al. 2024

Genet Sel Evol

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Background There are 13 known chicken blood systems, which were originally detected by agglutination of red blood cells by specific alloantisera. The genomic region or specific gene responsible has been identified for four of these systems (A, B, D and E). We determined the identity of the gene responsible for the chicken blood system I, using DNA from multiple birds with known chicken I blood system serology, 600K and 54K single nucleotide polymorphism (SNP) data, and lowpass sequence information. Results The gene responsible for the chicken I blood system was identified as RHCE, which is also one of the genes responsible for the highly polymorphic human Rh blood group locus, for which maternal/fetal antigenic differences can result in fetal hemolytic anemia with fetal mortality. We identified 17 unique RHCE haplotypes in the chicken, with six haplotypes corresponding to known I system serological alleles. We also detected deletions in the RHCE gene that encompass more than 6000 bp and that are predicted to remove its last seven exons. Conclusions RHCE is the gene responsible for the chicken I blood system. This is the fifth chicken blood system for which the responsible gene and gene variants are known. With rapid DNA-based testing now available, the impact of I blood system variation on response against disease, general immune function, and animal production can be investigated in greater detail.

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A Case Report of a Rare Rh Phenotype: D—

Cited by 5 publications

References 10 publications

Neonatal hemolytic anemia due to the mother's rare RhD^–/– phenotype: A case report

Neonatal hemolytic anemia due to the mother's rare RhD^–/– phenotype: A case report

D‐‐phenotype due to RHD‐RHCE hybrid transcript in a case of severe haemolytic disease of newborn with anti‐Rh 17(Hrₒ) antibodies

The RHCE gene encodes the chicken blood system I

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A Case Report of a Rare Rh Phenotype: D—

Cited by 5 publications

References 10 publications

Neonatal hemolytic anemia due to the mother's rare RhD–/– phenotype: A case report

Neonatal hemolytic anemia due to the mother's rare RhD–/– phenotype: A case report

D‐‐phenotype due to RHD‐RHCE hybrid transcript in a case of severe haemolytic disease of newborn with anti‐Rh 17(Hrₒ) antibodies

The RHCE gene encodes the chicken blood system I

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Neonatal hemolytic anemia due to the mother's rare RhD^–/– phenotype: A case report

Neonatal hemolytic anemia due to the mother's rare RhD^–/– phenotype: A case report