A case report of adolescent respiratory epithelial adenomatoid hamartoma

Abstract

Hamartomas are common in the lung, kidney, liver, spleen, and, but rare, in the sinonasal tract. Respiratory epithelial adenomatoid hamartomas (REAHs) are benign lesions common in men aged 30 to 90 years. Approximately 70% of REAHs in the head and neck region originate from the posterior nasal septum. We present an unusual case of REAH originating from the maxillary sinus and extending to the nasopharynx of an adolescent boy. A 17-year-old boy without any salient medical history presented to our department with nasal obstruction that had persisted for 7 years as well as greenish nasal discharge, hyposmia, and a complaint of fetid smell. Sinoscopy of the osteomeatal complex (OMC) revealed bilateral mucopus and a large right polypoid tumor extending into the nasopharynx. Computed tomography of the paranasal sinuses revealed soft-tissue opacification around the right OMC, frontal sinus, ethmoid sinus, maxillary sinus, and nasopharynx. We performed bilateral endoscopic sinus surgery. REAH and chronic rhinosinusitis with nasal polyps were diagnosed on the basis of a pathology report. No evidence of recurrence was observed by 6 months after surgery, and his hyposmia, nasal obstruction, and purulent nasal discharge were alleviated considerably. Accurate diagnosis based on pathology is essential for determining the optimal treatment, which for REAH is complete surgical excision.

Nasopharyngeal Respiratory Epithelial Adenomatoid Hamartoma—Master of Masquerade

“…4,6 Lesions in the nasopharynx are still rarely described in the literature and in most cases, a more sinister diagnosis was initially suspected in lesions which extended into the nasopharynx, especially in patients who had significant other comorbid diseases. 3,7,8 Of the 394 cases included in a review by Nguyen et al there was only one case described to occur in the nasopharynx. 4 REAH is a condition which is difficult to diagnose based on clinical or radiological features.…”

Respiratory epithelial adenomatoid hamartoma: A rare differential diagnosis of sinonasal mass

“…Its clinical and radiological presentation is not specific and may mimic an inverted papilloma or adenocarcinoma or olfactory neuroblastoma. 2 Clinicians nowadays are more aware of this entity and pre surgical diagnosis may be discussed especially with better knowledge of certain features . Being well aware of this entity can either prevent overly aggressive resection or, conversely, incomplete resection.…”

Respiratory epithelial adenomatoid hamartoma in a child with nasal polyposis. Case report

“…Гамартома -опухолевидное образование дизэмбриологической природы, состоящей из нормальных, но неорганизованных клеток [4]. В большинстве случаев данные образования диагностируются в легких, почках, печени, селезенке, коже, а синоназальные гамартомы встречаются крайне редко [5]. В зависимости от гистологической характеристики они подразделяются на 4 группы: респираторная эпителиальная аденоматоидная гамартома (РЭАГ), серомуцинозная гамартома (СГ), хондро-костная респираторная эпителиальная гамартома (ХКРЭГ) и хондромезенхимальная гамартома носа (ХМГН).…”