A case report of diabetic foot ulcer underwent an autolytic debridement using hydrogel and hydrocellular foam combination

Irawan, Hendry; Yasa, Ketut Putu

doi:10.15562/bmj.v6i3.411

Cited by 6 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various antibacterial contact-active hydrogel coatings have been reported, 19,20 of bacteria and do not eradicate biofilm bacteria. Debridement (i.e., removal of bacteria and endotoxin from the infection site) by enzymes has been reported 21,22 but not by nonleaching mechanisms such as diffusion or advection in fluid flow as reported here. Debridement can reduce inflammation and is critically important for the healing of chronic wounds.…”

Section: Introductionsupporting

confidence: 52%

“…Various antibacterial contact-active hydrogel coatings have been reported, , but these are typically for prophylactic treatment of bacteria and do not eradicate biofilm bacteria. Debridement (i.e., removal of bacteria and endotoxin from the infection site) by enzymes has been reported , but not by nonleaching mechanisms such as diffusion or advection in fluid flow as reported here. Debridement can reduce inflammation and is critically important for the healing of chronic wounds. , Debridement resulting in bacterial translocation away from the infection site followed by ex situ killing is a novel concept for anti-biofilm contact-active hydrogel.…”

Section: Introductionmentioning

confidence: 46%

“…aeruginosa (PA), including methicillin-resistant S. aureus (MRSA USA300) and carbapenem-resistant Gram-negative AB and PA strains (CR-AB and CR-PA), which are pathogens of great concern worldwide. , The other hydrogels (1b–1e and series 2) do not completely eradicate the bacteria. An agar diffusion test performed with P.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo

Yeo

Vikhe

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Multidrug resistance and the refractory character of bacterial biofilms are among the most difficult challenges in infection treatment. Current antimicrobial strategies typically are much more effective for prevention of biofilm formation than for eradication of established biofilms; these strategies also leave dead bacteria and endotoxin in the infection site, which impairs healing. We report a novel hydrogel that eradicates biofilm bacteria by non-leaching-based debridement followed by ex situ contact-killing (DESCK) away from the infection site. The debridement effect is likely due to the high water swellability and microporosity of the cross-linked network which is made from polyethylene glycol dimethacrylate tethered with a dangling polyethylenimine (PEI) star copolymer. The large pore size of the hydrogel makes the cationic pore walls highly accessible to bacteria. The hydrogel also degrades in the presence of infection cells, releasing star cationic PEI into the infection site to contact-kill bacteria remaining there. DESCK hydrogel effectively kills (>99.9% reduction) biofilms of methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Pseudomonas aeruginosa (CR-PA) and Acinetobacter baumannii in a murine excisional wound infection model. Silver-based wound dressings (controls) showed almost no killing of CR-PA and MRSA biofilms. This DESCK hydrogel greatly reduces the bioburden and inflammation and promotes wound healing. It has great potential for diverse infection treatment applications.

show abstract

Section: Introductionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 46%

See 1 more Smart Citation

Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo

Yeo

Vikhe

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…An ulcer occurs because, at tissue damage or death, that associated with the degree of peripheral vascular disease in inferior limb and may be accompanied by infection [4], [5]. It is estimated 15-25% of DM patients will develop DFUs with high morbidity, 40-80% will have high infection risk, and 10-20% will require amputation [6].…”

Section: Introductionmentioning

confidence: 99%

“…The standard therapies of DFUs are to regulate normal blood sugar levels, antibiotics medication to prevent and treat infection, ulcer debridement, wound care, off-loading the affected limb, and to improve blood flow or revascularisation [2], [6], [7], [8], [9]. In addition to these standard therapies, there are many adjuvant therapies, such as hyperbaric oxygen therapy (HBOT), growth factor therapy, stem cells therapy [7], [10], autolytic debridement [4], and percutaneous transluminal angioplasty [11]. These modalities are also performed in the management of DFUs.…”

Section: Introductionmentioning

confidence: 99%

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy

Semadi¹

2019

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Around 15-25% of diabetes mellitus (DM) patients will develop diabetic foot ulcers (DFUs) with high morbidity, many studies have been proposed to search the most effective healing techniques. AIM: This study was conducted to demonstrate the ability of hyperbaric oxygen therapy (HBOT) as a complementary therapy in DFUs healing through raising vascular endothelial growth factor (VEGF) levels and suppressing tumour necrosis factor-alpha (TNF-α). METHODS: All patients received the same treatment including wound debridement and wound care, but the patients in the HBOT group, breathed 100% oxygen at 2.4 ATA for 90 minutes in total of 20 sessions (four weeks). RESULT: There were 32 diabetic patients with DFUs Wagner 3-4. VEGF levels after four weeks of HBOT was significantly elevated compared to the control group (p = 0.013). The effect size of VEGF levels was p = 0.005. TNF-α levels after four weeks of therapy were decreased (p = 0.01). Faster epithelialization is seen in the HBOT group (p < 0.001). We also performed path analysis, HBOT had a significant effect on the epithelialization (p < 0.001) and VEGF levels affected the epithelialization process (p = 0.042). CONCLUSION: HBOT administration leads to increased VEGF levels, decreased TNF-α levels, and accelerated wound healing of DFUs patients. HBOT directly aids epithelialization and indirectly through VEGF upsurge and TNF-α downturn.

show abstract

Inhibition and eradication of bacterial biofilm using polymeric materials

Banerjee

Chowdhury

Bauri³

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

A case report of diabetic foot ulcer underwent an autolytic debridement using hydrogel and hydrocellular foam combination

Cited by 6 publications

References 0 publications

Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo

Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy

Inhibition and eradication of bacterial biofilm using polymeric materials

Contact Info

Product

Resources

About