A case report of extensive segmental defect of the humerus due to thermal necrosis treated with Masquelet technique

Mukhopadhaya, John; Gautam, Kumar; Bhadani, Janki Sharan

doi:10.1016/j.tcr.2021.100544

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…5 The IMT has demonstrated successful results for defects ranging from 5 to 24 cm and in both upper and lower extremity defects for septic and aseptic nonunions. 6,7,14–19 In this case, the patient did not return for a second bone grafting procedure until 8 weeks after her first stage IMT to fully eradicate her infection. This is on the tail end of what has been described as the optimal bone grafting window and may have had an effect on the healing potential of her bone graft because she did require a secondary bone graft procedure to achieve union.…”

Section: Discussionmentioning

confidence: 97%

Infected humeral shaft nonunion treatment with the induced membrane technique and a novel fixation construct: a case report

Fisher,

Konda

2023

OTA International

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Case: A 51-year-old woman with an infected left humeral shaft recalcitrant nonunion presented 3 years after initial injury. This case report focuses on the staged treatment of a 17-centimeter (cm) humeral shaft nonunion with the induced membrane technique (IMT) using a unique fixation construct of dual locked plating around a humeral nail to provide long-lasting fixation and allow for bone graft consolidation. Conclusion: Large segmental bone loss of the humerus can be treated with the IMT using nail-plate fixation constructs that allow for early mobilization, increased time for bone graft consolidation before hardware failure, and less frequent follow-up.

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Section: Discussionmentioning

confidence: 97%

Infected humeral shaft nonunion treatment with the induced membrane technique and a novel fixation construct: a case report

Fisher,

Konda

2023

OTA International

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“…The use of fixation devices has shown some major drawbacks, such as infection and immune responses, bone adsorption, stress shielding, osteoporosis, and the need for a second surgery to remove the implanted devices (e.g., orthopedic screw) after bone healing 4 . Bone cement was also an inadequate option due to its low porosity and compact structure, which impelled the bone parts toward death 5 . Segmental bone tissue engineering is a novel approach to the regeneration of large bone defects 6 .…”

Section: Introductionmentioning

confidence: 99%

“…4 Bone cement was also an inadequate option due to its low porosity and compact structure, which impelled the bone parts toward death. 5 Segmental bone tissue engineering is a novel approach to the regeneration of large bone defects. 6 The size of the scaffolds is a key factor that directly affects cell migration and viability.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

Khodabakhshi,

Soleimanimehr,

Etemadi Haghighi

et al. 2023

Polymer Engineering & Sci

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Segmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this article, 3D printing was used to fabricate the polycaprolactone (PCL)/NaCl‐based cylindrical structures. The effects of the structure's thickness (L) and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD). Results showed that increasing the NaCl concentration up to 10% wt significantly improved the degradability, swelling, and hydrophilicity of the structures. It was also indicated that the maximum stiffness of the guide structures under vertical loading was almost five times larger than the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. Results indicated that the mechanical properties of the structures were more dependent on the structure thickness so the thicker structures with an 800 μm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the nontoxic effect of the PCL structures on the MC3T3 osteoblast cell line. Based on the results, the PCL‐based structures were a suitable candidate to act as a guide for segmental bone tissue engineering.Highlights A 3D‐printed conduit was manufactured to guide bone reconstruction Response surface methodology (RSM) using central composite design (CCD) was employed NaCl concentration and the diameter of strands were the main parameters This 3D‐printed guiding approach is useful for segmental bone tissue engineering

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“…The use of xation devices has shown some major drawbacks, such as infection and immune responses, bone adsorption, and stress shielding, osteoporosis, and the need for a second surgery to remove the implanted devices (e.g., orthopedic screw) after bone healing (Moghaddam, Andani et al 2016). Bone cement was also an inadequate option due to its low porosity and compact structure, which impelled the bone parts towards death (Mukhopadhaya, Gautam et al 2021). Segmental bone tissue engineering is a novel approach to the regeneration of large bone defects (Alkindi, Ramalingam et al 2021).…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of PCL-based film for guiding segmental bone defect

Khodabakhshi

Soleimanimehr

Haghighi

et al. 2022

Preprint

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Segmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this paper, a PCL-based guide film was developed for controlling segmental bone tissue engineering. 3D bioprinting was used to fabricate the PCL/NaCl-based cylindrical films. The effects of the film's thickness and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD) results showed that increasing the NaCl concentration up to 10% wt. significantly improved the degradability, swelling, and hydrophilicity of the films. It was also indicated that the maximum stiffness of the guide films under vertical loading was almost 5 times more than the maximum stiffness in the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. All the evidence indicated that the mechanical properties of the films were more dependent on the film thickness so the thicker films with an 800µm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the non-toxic effect of the PCL films on the MC3T3 osteoblast cell line. Based on the results, the PCL-based films were a suitable candidate to act as a guide for segmental bone tissue engineering.

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A case report of extensive segmental defect of the humerus due to thermal necrosis treated with Masquelet technique

Cited by 4 publications

References 11 publications

Infected humeral shaft nonunion treatment with the induced membrane technique and a novel fixation construct: a case report

Infected humeral shaft nonunion treatment with the induced membrane technique and a novel fixation construct: a case report

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

In-vitro evaluation of PCL-based film for guiding segmental bone defect

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