Genital warts, commonly known as condyloma acuminate (CA), caused by the proliferation of squamous epithelial cells in the presence of sexually transmission of human papilloma virus (HPV) infection. There are several modalities of treatment options available for genital warts, medical and/or surgical. We present a case of 23-year-old primigravida who presented with giant extensive genital warts. Lesions were treated using; cryotherapy, sub-lesional vitamin D3, acyclovir, and Trichloro-acetic acid 50% (TCA).