A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

Leerunyakul, Kanchana; Chirasuthat, Phatcharawat; Suchonwanit, Poonkiat

doi:10.1159/000503272

Cited by 4 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, SFH is most commonly reported to develop on the chin and neck. 7 , 8 On the contrary, lichen spinulosus most commonly presents with patches of follicular papules with keratotic spines upon the trunk and extremities 9 just like our case. Since the clinical locations of our case were more compatible with typical lichen spinulosus than SFH, the final diagnosis was lichen spinulosus.…”

supporting

confidence: 48%

Lichen spinulosus following COVID‐19 infection: Another possible cutaneous manifestation of COVID‐19?

Cakir

Bostan²,

Gököz

2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

supporting

confidence: 48%

Lichen spinulosus following COVID‐19 infection: Another possible cutaneous manifestation of COVID‐19?

Cakir

Bostan²,

Gököz

2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

“…13 28 Other known associations are Crohn's disease, hypovitaminosis A, chronic renal failure, human immunodeficiency virus infection, cryoglobulinemia, Sezary syndrome, and lymphoma. 13 14 28…”

Section: Discussionmentioning

confidence: 99%

“…Treatment of SFH with topical retinoids, fluocinolone acetonide gel, and 12% lactic acid cream has been tried in the past with little benefit. 14 28 Discontinuation of the causative drug or management of the underlying condition is considered the definitive treatment. 13 28 Among the 11 cases of sorafenib-induced SFH in literature, six patients showed complete clearance of the rash on discontinuing sorafenib, with recurrence seen in three patients on reinstitution of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15][16]28 Paraproteinemia, particularly multiple myeloma, is the earliest known association and most frequently linked to SFH in literature. 13,28 Other known associations are Crohn's disease, hypovitaminosis A, chronic renal failure, human immunodeficiency virus infection, cryoglobulinemia, Sezary syndrome, and lymphoma. 13,14,28 Unlike HFSR, SFH is not a dose-limiting AE.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sorafenib-Induced Spiny Follicular Hyperkeratosis: A Case Report with Review of Literature

Shajil

Sathishkumar

Boddu

et al. 2023

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

Sorafenib is a multikinase inhibitor used in the treatment of various solid tumors. Mucocutaneous adverse events are experienced by 70 to 90% of the patients receiving sorafenib, underscoring the importance of awareness among oncologists and dermatologists. Spiny follicular hyperkeratosis (SFH) is a benign and rarely reported skin reaction linked to sorafenib. It is characterized by flesh-colored or white, follicular hyperkeratotic spicules, preferentially involving the face, scalp, upper trunk, and upper arms. Besides being acknowledged as a paraneoplastic cutaneous manifestation of multiple myeloma, SFH has also been linked to a few diseases and drugs, other than sorafenib. However, the precise etiopathogenesis remains to be elucidated. We report an interesting case of SFH in a 14-year-old child, 1 week following the initiation of sorafenib. Trichodysplasia spinulosa, multiple minute digitate hyperkeratosis, keratosis pilaris, filiform warts, and pityriasis rubra pilaris are morphologically similar conditions that were excluded by clinicopathological correlation. A complete resolution of skin rash following sorafenib dose reduction further reinforced our diagnosis. Our patient also developed hand-foot skin reaction, facial erythema, and eruptive nevi during treatment. The regrowth of curly hair following chemotherapy-induced anagen effluvium was an interesting development in our case. We report this case to familiarize clinicians with this rare entity.

show abstract

“…We also introduce a classification of GP on purpose that, hopefully, will lead to better characterization for this condition. Clinicians should consider follicular GP in the differential diagnosis of multiple filiform hyperkeratotic lesions, especially on the face or intertriginous area [25].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Follicular Granular Parakeratosis: A Case Report, Literature Review, and Proposed Classification

Chirasuthat

Suchonwanit³

2021

Skin Appendage Disord

Self Cite

View full text Add to dashboard Cite

Granular parakeratosis (GP) is a distinctive acquired keratotic dermatosis that is usually presented with brownish-red hyperkeratotic papules and plaques in the intertriginous areas. Follicular involvement in GP could be either extending lesions from interfollicular epithelium or originating primarily from the follicular epithelium. The latter was named follicular GP and is considered an extremely rare condition. To our knowledge, there has been one reported case so far in the literature. We herein report the second case of follicular GP in a 52-year-old Thai man presenting with multiple tiny filiform hyperkeratotic papules on his face 2 weeks after using anti-melasma cream. We also propose a classification of GP based on its distinct clinical manifestations and histopathological findings.

show abstract

A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

Cited by 4 publications

References 28 publications

Lichen spinulosus following COVID‐19 infection: Another possible cutaneous manifestation of COVID‐19?

Lichen spinulosus following COVID‐19 infection: Another possible cutaneous manifestation of COVID‐19?

Sorafenib-Induced Spiny Follicular Hyperkeratosis: A Case Report with Review of Literature

Follicular Granular Parakeratosis: A Case Report, Literature Review, and Proposed Classification

Contact Info

Product

Resources

About