A case report of metastatic mixed adeno-neuroendocrine carcinoma of the anus presenting as anal pain

Lim, Li Xian; Robles, Marie Shella De; Winn, Robert; Hart, Kimberly

doi:10.1016/j.ijscr.2020.04.065

Cited by 3 publications

(1 citation statement)

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“…The incidence and prevalence of MiNENs are not clear and are probably underestimated. According to the Rare Cancer Surveillance (RARECARE) project of the European Union, in 2008 the incidence was less than 0.1/100000 people per year and there were only 96 cases of MANEC in the entire continent ( )[ 22 ]. MiNENs account for less than 5% of all digestive NE neoplasms[ 5 , 13 ], although the incidence is probably increasing due to the improvement in diagnostic methods.…”

Section: Epidemiology and Locations In Gastroenteropancreatic Tractmentioning

confidence: 99%

Mixed neuroendocrine non-neuroendocrine neoplasms in gastroenteropancreatic tract

Díaz-López,

Jiménez-Castro,

Robles-Barraza

et al. 2024

World J Gastrointest Oncol

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Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are a heterogeneous group of malignant neoplasms that can settle in the gastroenteropancreatic tract. They are composed of a neuroendocrine (NE) and a non-NE component in at least 30% of each tumour. The non-NE component can include different histological combinations of glandular, squamous, mucinous and sarcomatoid phenotypes, and one or both of the components can be low-or high grade malignant. Recent changes in the nomenclature of these neoplasms might lead to great deal of confusion, and the lack of specific clinical trials is the main reason why their management is difficult. The review aims to clarify the definition of MiNEN and analyze available evidence about their diagnosis and treatment options according to their location and extension through careful analysis of the available data. It would be important to reach a general consensus on their diagnosis in order to construct a classification that remains stable over time and facilitates the design of clinical trials that, due to their low incidence, will require long recruitment periods.

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Section: Epidemiology and Locations In Gastroenteropancreatic Tractmentioning

confidence: 99%