A Case Report of Methimazole-Induced Acute Liver Failure Successfully Treated with Liver Transplantation

Jeon, Sung Jin; Kim, Tae Yong; Lee, Jun Young; Kang, Jong Sik; Choi, Gwang Hyeon; Lee, Seung Gyu; Hwang, Hyeon-Shik

doi:10.3904/kjm.2012.83.3.363

Cited by 5 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite many case reports indicating methimazole‐induced hepatotoxicity , no specific protective agent has been developed to treat antithyroid drugs‐induced liver damage in humans. Indeed, no clinical intervention except of drug cessation has been made for methimazole‐induced liver injury in most case reports .…”

Section: Introductionmentioning

confidence: 99%

“…Glyoxal and N-methylthiourea ( Figure 1) are two suspected toxic metabolites for methimazole that are assumed to be involved in the cellular injury and liver damage induced by this drug [5,6]. Despite many case reports indicating methimazole-induced hepatotoxicity [2,[11][12][13], no specific protective agent has been developed to treat antithyroid drugs-induced liver damage in humans. Indeed, no clinical intervention except of drug cessation has been made for methimazole-induced liver injury in most case reports [3,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Carbonyl Traps as Potential Protective Agents against Methimazole‑Induced Liver Injury

Heidari

Niknahad

Jamshidzadeh

et al. 2014

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Liver injury is a deleterious adverse effect associated with methimazole administration, and reactive intermediates are suspected to be involved in this complication. Glyoxal is an expected reactive intermediate produced during methimazole metabolism. Current investigation was undertaken to evaluate the role of carnosine, metformin, and N-acetyl cysteine as putative glyoxal (carbonyl) traps, against methimazole-induced hepatotoxicity. Methimazole (100 mg/kg, intraperitoneally) was administered to intact and/or glutathione (GSH)-depleted mice and the role of glyoxal trapping agents was investigated. Methimazole caused liver injury as revealed by an increase in serum alanine aminotransferase and aspartate aminotransferase. Moreover, lipid peroxidation and protein carbonylation occurred significantly in methimazole-treated animals' liver. Hepatic GSH reservoirs were decreased, and inflammatory cells infiltration was observed in liver histopathology. Methimazole-induced hepatotoxicity was severe in GSH-depleted mice and accompanied with interstitial hemorrhage and necrosis of the liver. Glyoxal trapping agents effectively diminished methimazole-induced liver injury both in intact and/or GSH-depleted animals.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carbonyl Traps as Potential Protective Agents against Methimazole‑Induced Liver Injury

Heidari

Niknahad

Jamshidzadeh

et al. 2014

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…갑상선기능항진증의 치료제로는 티오미다졸(메티마졸, 카비마 졸)과 프로필타이오우라실(propylthiouracil, PTU) 등이 흔히 사 용된다 [1]. 항 갑상선제의 부작용은 두드러기나 발진, 관절염, 소화 불량과 같은 경미한 것에서 [2] 드물게는 생명을 위협하는 무 과립 구증이나 독성간염과 같은 중증 부작용까지 다양하게 발생할 수 있다 [1]. 특히 PTU는 전격성 간염을 일으켜 간 이식수술이 필요한 경우도 보고되어 [3,4], 대한갑상선학회와 [3] 미국 갑상선학회 및 미 국 임상내분비의사회에서 [4]…”

Section: 서 론unclassified

Methimazole-Induced Acute Cholestatic Hepatitis in a Patient with History of Simvastatin-Induced Liver Injury

Kwak¹,

Kim²,

Park³

et al. 2014

Soonchunhyang Med Sci

View full text Add to dashboard Cite

Methimazole and prophylthiouracil are commonly prescribed for patients with hyperthyroidism. The serious side effect of toxic hepatitis caused by these two drugs is well known. According to recent Korean and American management guidelines for hyperthyroidism, mehimazole is recommended as the first-choice antithyroid drug for the treatment of hyperthyroidism. Toxic hepatitis rarely occurs in methimazole users. We report a rare case of a 52-year-old female with toxic hepatitis after methimazole use that had past medical history of simvastatin induced liver injury.

show abstract

“…Several adverse events are attributed to methimazole administration, including deleterious ones such as agranulocytosis and hepatotoxicity [ 5 – 7 ]. Although several cases of methimazole-induced hepatic injury were reported [ 6 – 10 ], no specific protective agents have been developed against this complication so far. Different mechanisms have been proposed to be involved in methimazole-induced liver injury.…”

Section: Introductionmentioning

confidence: 99%

Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice

et al. 2015

View full text Add to dashboard Cite

Methimazole is the most widely prescribed antithyroid medication in humans. However, hepatotoxicity is a deleterious adverse effect associated with methimazole administration. No specific protective agent has been developed against this complication yet. This study was designed to investigate the role of taurine as a hepatoprotective agent against methimazole-induced liver injury in mice. Different reactive metabolites were proposed to be responsible for methimazole hepatotoxicity. Hence, methimazole-induced liver injury was investigated in intact and/or enzyme-induced animals in the current investigation. Animals were treated with methimazole (200 mg/kg, by gavage), and hepatic injury induced by this drug was investigated in intact and/or enzyme-induced groups. Markers such as lipid peroxidation, hepatic glutathione content, alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in plasma, and histopathological changes in the liver of animals were monitored after drug administration. Methimazole caused liver injury as revealed by increased plasma ALT. Furthermore, a significant amount of lipid peroxidation was detected in the drug-treated animals, and hepatic glutathione reservoirs were depleted. Methimazole-induced hepatotoxicity was more severe in enzyme-induced mice. The above-mentioned alterations in hepatotoxicity markers were endorsed by significant histopathological changes in the liver. Taurine administration (1 g/kg, i.p.) effectively alleviated methimazole-induced liver injury in both intact and/or enzyme-induced animals.

show abstract

A Case Report of Methimazole-Induced Acute Liver Failure Successfully Treated with Liver Transplantation

Cited by 5 publications

References 9 publications

Carbonyl Traps as Potential Protective Agents against Methimazole‑Induced Liver Injury

Carbonyl Traps as Potential Protective Agents against Methimazole‑Induced Liver Injury

Methimazole-Induced Acute Cholestatic Hepatitis in a Patient with History of Simvastatin-Induced Liver Injury

Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice

Contact Info

Product

Resources

About