A Case Report of Metronidazole Induced Neurotoxicity in Liver Abscess Patient and the Usefulness of MRI for its Diagnosis

MRI findings of metronidazole neurotoxicity in a pediatric patient with chronic diarrhea

“…A case presented by Chandak et al discussed a 45-year-old patient undergoing 4 weeks of metronidazole therapy for a liver abscess, who presented with staccato speech and ataxia. MRI demonstrated abnormal increased T2 signal in the dentate nuclei as well as the midbrain tectum [ 8 ]. As with the case reported by Kalia et al [ 7 ], enhancement characteristics were not discussed.…”

Garbled speech: a rare presentation of metronidazole-induced neurotoxicity

“…However, a clear temporal relationship with metronidazole intake and reversibility of symptoms on its discontinuation along with standard metabolic profile plus no clinical evidence of maple syrup urine disease and Wernicke’s encephalopathy make the diagnosis of metronidazole-induced neurotoxicity unquestionable in our case. Chandak et al suggested that recognising the pattern of imaging abnormality is significant as terminating the use of metronidazole can result in rapid clinical improvement and resolution of signal changes 11…”

Metronidazole Induced Cerebellar Ataxia: A Rare Case Report

“…4 Shruthi Chandak et al reported a case of 45 yr. old man who received around 62gm of Metronidazole for 26 days for liver abscess presented with cerebellar signs. 5 The exact mechanism is not known, but it is said that in susceptible individuals the Metronidazole and its toxic metabolites bind to neuronal RNA and causes reversible axonal swelling. 6 Other theories like interstitial oedema and ischemia and Purkinje cell damage has also been put forward.…”