A Case Report of Mikulicz Syndrome

Abstract

Mikulicz Syndrome (MS) is a rare chronic condition characterized by the abnormal enlargement of glandular tissue in the head and neck. Patients usually present with enlarged lacrimal and parotid glands. While this can be a benign self-limiting condition, other complex systemic diseases, such as sarcoidosis, may represent other underlying etiologies. We present a case of MS in a patient with a history of Crohn's disease.

Sarcoidosis appeared as Mikulicz’s syndrome : a Case report

“…Johann Mikulicz first presented Mikulicz Disease (MD) in 1888 at a meeting of the Society for Scientific Medicine in Königsberg. He later published a report of this sentinel case detailing a 42 year-old man with initial symptoms of lacrimal gland swelling followed by submandibular and parotid swelling [1] Classic symptoms of MD are xerostomia and parotid enlargement Dry eyes and lacrimal gland enlargement are also commonly reported symptoms. Parotid and lacrimal gland enlargement has been reported with both bilateral and unilateral distribution, in concurrence, or in isolation [2] The term Mikulicz Disease should be reserved for cases that follow a benign course and are of unknown etiology.…”

“…While this can be a benign self-limiting condition, other complex systemic diseases, such as sarcoidosis, may represent other underlying etiologies. [1] We report a case of MS in a 25-year-old female that was found to be secondary to sarcoidosis…”

Tattoo-associated lacrimal gland enlargement and sarcoidosis

“…When these symptoms are attributed to a known underlying cause, including Sjogren syndrome, sarcoidosis, lymphoma, and tuberculosis, this condition is termed Mikulicz syndrome (MS). 3 While the causes of sarcoidosis are not well understood, tattoos have been associated with systemic and ocular sarcoidosis. This case report describes a patient with Mikulicz syndrome resulting from tattoo-associated sarcoidosis.…”