A case report of mucocutaneous tuberculosis after orthotopic liver transplantation: a challenging diagnosis

Riccardi, Niccolò; Cenderello, Giovanni; Borroni, Emanuele; Rutigliani, Mariangela; Cirillo, Daniela María

doi:10.1186/s12879-018-3347-7

Cited by 3 publications

(2 citation statements)

References 18 publications

(20 reference statements)

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“…The most common site of infection is the lung, but other organs may be involved 1 including the kidney, spine, and brain, skin, etc. 2,3 The cornerstone of TB management is a 6-month course of using anti-TB drugs where isoniazid, rifampicin, pyrazinamide, and ethambutol are taken for 2 months in the intensive phase followed by a fourth month use of isoniazid and rifampicin in the continuous phase of managing protocols of the disease. Compliance is crucial for curing TB.…”

Section: Introductionmentioning

confidence: 99%

Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia

Molla¹,

Wubetu²,

Dessie³

2021

HMER

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Background Tuberculosis caused by susceptible mycobacterium tuberculosis strains is effectively treated by the first-line anti-tuberculosis drugs. However, most antibacterial drugs are known to induce hepatotoxicity which may limit their adherence and hence lead to the development of mycobacterial drug resistance. Objective The aim of this study was to assess the incidence of anti-tuberculosis drug induced hepatotoxicity and associated factors among tuberculosis patients of Debre Markos, Mota, and Bichena Hospitals. Methods The prospective cross sectional-study was conducted in three hospitals of East Gojjam zone by taking blood samples of new tuberculosis patients every 2 weeks for 2 months to measure the elevation of liver proteins indicating liver toxicity from the onset of starting therapy. A semi-structured questionnaire was also used to collect the socio-demographic data and factors of anti-tubeculosis drug induced liver toxicity. To identify factors associated with drug induced hepatotoxicity, binary logistic regression followed by multivariate analysis was applied at a statistically significant level of P <0.05. Results The incidence of hepatotoxicity among tuberculosis patients is 7.9%. Diagnosis of extrapulmonary tuberculosis, having comorbid disease, and old age are significantly associated ( P <0.05) with first-line antituberculosis drugs induced hepatotoxicity. Conclusion The incidence of hepatotoxicity is relatively high among tuberculosis patients taking first-line anti-tuberculosis drugs. Therefore, the liver function of patients with old age, comorbid diseases, and extrapulmonary tuberculosis should be regularly monitored to reduce the severity of drug-induced hepatotoxicity.

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Section: Introductionmentioning

confidence: 99%

Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia

Molla¹,

Wubetu²,

Dessie³

2021

HMER

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“…Tuberculosis (TB) is mainly a disease of the lungs; however, it can affect any organ (extra-pulmonary TB, EPTB), often resulting in challenging diagnoses. 1,2 Genito-urinary TB (GUTB), after TB of the lymph nodes, is the most frequently incident EPTB form. Mycobacterium tuberculosis (MTB) can be found in the kidneys, prostate, and epididymis A rare case of multi-focal human TB after BCG instillation for non-muscle-invasive bladder cancer after its haematogenous spread during primary TB infection.…”

Section: Introductionmentioning

confidence: 99%

A rare case of multi-focal human TB after BCG instillation for non-muscle-invasive bladder cancer

et al. 2019

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Objective: To describe a left epididymitis and para-aortical involvement caused by Mycobacterium tuberculosis hominis reactivation after bacillus Calmette-Guérin instillation for non-muscle-invasive bladder cancer. Patient and methods: A Caucasian male, aged 76 years, exposed to bacillus Calmette-Guérin for a high-grade non-muscle-invasive bladder cancer in 2015, reported painful and progressive left scrotal swelling with purulent discharge from a cutaneous fistulous track that yielded, on liquid culture, a pan-susceptible Mycobacterium tuberculosis hominis strain. Moreover, after 6 months of anti-tuberculosis treatment, an abdominal peri-aortic mass, sized 4 cm, was found and a surgical biopsy showed necrotizing granulomas; however, although smear microscopy and Xpert MTB/Rif™ performed on fresh biopsy sample were positive, liquid cultures resulted negative, indicating treatment efficacy. Results: Numerous peculiar and multi-organ involvement due to BCGitis after intravesical immunotherapy have been previously described, including 17 scientific articles about epididymitis, however, no reports so far showed reactivation of Mycobacterium tuberculosis hominis after bacillus Calmette-Guérin treatment. Conclusion: Although BCGitis is more prevalent in patients undergoing bacillus Calmette-Guérin instillation for non-muscle-invasive bladder cancer, tuberculosis by other species of Mycobacterium tuberculosis should be always ruled out by molecular and conventional microbiology in patients with a history of Mycobacterium tuberculosis hominis exposure.

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Cutaneous Tuberculosis in Heart Transplant

Lino

Amorim

Silva

et al. 2023

Transplantation Proceedings

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A case report of mucocutaneous tuberculosis after orthotopic liver transplantation: a challenging diagnosis

Cited by 3 publications

References 18 publications

Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia

Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia

A rare case of multi-focal human TB after BCG instillation for non-muscle-invasive bladder cancer

Cutaneous Tuberculosis in Heart Transplant

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