A Case Report of Olanzapine-Induced Hypersensitivity Syndrome

Raz, Ayelet; Eilam, Oron; Hayek, Tony; Bergman, Reuven; Yungerman, Tal

doi:10.1097/00000441-200102000-00008

Cited by 66 publications

(24 citation statements)

References 11 publications

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“…Clinical features and the results of skin and liver biopsies indicated that the patients developed hypersensitivity syndrome [25] .…”

Section: Discussionmentioning

confidence: 98%

Histological Study of the Effects of Olanzapine on the Liver of Adult Male Albino Rat with and without Vitamin C

Elbakary

2017

Egyptian Journal of Histology

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Introduction: Olanzapine is an atypical antipsychotic drug widely used in treatment of schizophrenia for prolonged time. Aim of the work: The present study was carried out to evaluate the effect of olanzapine on the liver and the possible protective effect of vitamin C. Material and Methods: Forty adult male albino rats were used in this work. They were divided into: Group I as a control, group II was given Olanzapine (2mg/kg B. wt. orally once daily) for one month, group III was given Olanzapine (at the same previous dose) plus vitamin C (15 mg /Kg. B. wt of orally once daily) for one month and group IV was given only vitamin C (for the same dose and period of the previous group). At the end of the experiment, liver specimens were processed for histological study by light and electron microscopes. Also blood samples were collected for estimation of liver enzymes. Result: Significant increase in the level of liver enzymes was observed in Olanzapine treated group. While the microscopic examination of the liver sections of this group revealed several histological changes including, dilatation and congestion of central veins and blood sinusoids, inflammatory cellular infiltration in the portal areas and cytoplasmic vacuolation of hepatocytes that present mainly around the central veins. Mitochondrial degeneration, bile ducts dilatation and excessive deposition of lipid droplets were also observed. These changes were ameliorated by vitamin C administration. Conclusion: Results of this experimental work revealed that administration of vitamin C greatly reduced the histological alterations induced by Olanzapine, suggesting that vitamin C has a protective effect on the liver.

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“…Clinical features and the results of skin and liver biopsies indicated that the patients developed hypersensitivity syndrome [25] .…”

Section: Discussionmentioning

confidence: 98%

Histological Study of the Effects of Olanzapine on the Liver of Adult Male Albino Rat with and without Vitamin C

Elbakary

2017

Egyptian Journal of Histology

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“…[2][3][4][5] Although atypical antipsychotics cause fewer dermatologic symptoms than typical antipsychotics, 6 some recent reports have associated olanzapine [7][8][9] and clozapine 10-13 with skin lesions.…”

Section: Diagnosis Of Nonorganic Monoplegia With Single-pulse Transcrmentioning

confidence: 99%

Reexamining the Elderly Patient's Presentation With Depression

Barkin¹,

Barkin²

2008

Prim. Care Companion J. Clin. Psychiatry

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Section: Diagnosis Of Nonorganic Monoplegia With Single-pulse Transcrmentioning

confidence: 99%

“…Several case reports of psychotic episodes following Epstein-Barr virus infection, but without CFS symptoms, have also been described. [7][8][9] Mononucleosis could be responsible both for the development of CFS and for the psychotic disorder, if the EpsteinBarr virus remains latent and is reactivated in times of greater stress or immunologic weakness. 10 The frontal atrophy in our patient as well as in the 22-year-old patient described earlier could be a sequela of an Epstein-Barr virus-induced central nervous system insult.…”

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confidence: 99%