A Case Report of Successful Treatment of Mammary Myofibromyoblastoma in a Male Patient

Abstract

Myofibroblastoma (MFB) is an extremely rare benign tumor that can arise in various organs, but commonly in the breast. Albeit it is a benign tumor, the diagnosis is frequently challenging with insurmountable difficulties as it might be erroneously diagnosed as a malignancy. Herein we are reporting a large-sized MFB presented as a non-tender, firm mass which interestingly was adherent to the skin and was initially thought as cancer. The patient underwent a wide local excision and histology confirmed MFB, and had no evidence of recurrence up to 8 months post-operatively.

A Large Myofibroblastoma of the Breast in a Premenopausal Woman: A Case Report and Review of the Literature

“…Clinical presentation usually mimics fibroadenoma [10] with a solitary painless well-defined mobile mass, which grows slowly over months to several years [2]. Very few cases have reported adherence to the skin [1,3,11]. In our case, the tumor was tethered to the skin clinically, but was able to be separated from the subdermal tissue in the operating room, and histopathologic evaluation confirmed no invasion to subdermal tissue.…”

“…MFB is a very uncommon benign tumor. Although it can arise from various sites including skin, soft tissue, and lymph nodes, mammary MFB is the most common [3,7]. It is a mesenchymal tumor that originates from the breast stroma and belongs to the mammary benign spindle cell neoplasms [1].…”

“…Myofibroblastoma (MFB) of the breast is a very rare mesenchymal tumor, belonging to the benign spindle cell neoplasms [1,2]. The incidence of MFB is unknown but estimated to be less than 1% of breast tumors [3]. It was first described as a distinct entity by Wargotz et al in 1987, as a benign tumor of mammary stroma predominantly composed of myofibroblasts [4].…”