A case report of sudden-onset upper and lower extremity weakness

Haddad, Heba; Rotblatt, Michael

doi:10.1080/00913847.2015.1001715

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…In the day preceding or following an episode, the patient may encounter symptoms such as myalgia, paraesthesia, and excessive thirst. This can potentially lead to severe complications like respiratory failure and cardiac arrhythmias [1,11,13]. It may be triggered by strenuous physical activity, carbohydrate-rich meals, infections, and stress [5,12].…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Hypokalemic Periodic Paralysis With Acute Urinary Retention: Diagnosis and Management

Sara,

TV,

et al. 2024

Cureus

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Hypokalemic periodic paralysis (hypoPP) is a rare channelopathy caused by mutations in skeletal muscle ion channels that usually occurs in young individuals and adolescents. The etiology can be attributed to various factors, such as idiopathic or secondary causes. It is characterized by episodes of sudden flaccid muscle weakness. Timely detection may mitigate the risk of severe complications. Secondary causes of hypoPP, such as hyperthyroidism, should be ruled out, as this could lead to thyrotoxic periodic paralysis.We report the case of a 19-year-old boy who presented to the ED with severe weakness in both the upper and lower extremities. The weakness rapidly progressed to his trunk and was accompanied by acute urinary retention. The physical examination was significant for bilateral upper and lower extremity weakness. Subsequent laboratory investigations revealed markedly low serum potassium levels. The patient's symptoms resolved after the replacement of potassium, and he was discharged without neurological deficits. Although rarely accompanied by acute urinary retention, hypoPP must be differentiated from other causes of weakness and paralysis so that the proper treatment can be initiated quickly. The rarity of hypoPP, a condition seldom encountered in clinical practice, and the added rarity of its coexistence with acute urinary retention further underscore the uniqueness of this case report.

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Section: Discussionmentioning

confidence: 99%

“…The sudden attack of hypoPP episodes is linked more commonly with females than males [10]. In this disorder, hypokalemia is due to a sudden and large influx of potassium into the cells rather than the actual net loss of potassium [11].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Hypokalemic Periodic Paralysis With Acute Urinary Retention: Diagnosis and Management

Sara,

TV,

et al. 2024

Cureus

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“…Potassium replacement is not a long-term solution for these patients, as in between attacks, their serum potassium levels will most likely normalise. The definitive treatment for these patients is the management of the underlying cause, in this case, hyperthyroidism [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Thyrotoxic Periodic Paralysis: Case Presentation With Tetraparesis and Cardiac Dysrhythmia

Dosu¹,

Gupta²,

Walsh³

et al. 2022

Cureus

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Thyrotoxic hypokalaemic periodic paralysis (THPP) is a rare complication of hyperthyroidism that is potentially life-threatening if not treated promptly. It is more common in Asian and Polynesian populations and very few cases have been reported to date in people of White ethnicity. We present a case report of a young male patient of White ethnicity, who was initially brought in as a stroke alert with tetraparesis which was ruled out on initial assessment, but then had a syncopal episode and was noted to be initially bradycardic and subsequently tachycardic. Blood tests showed hypokalaemia and hypophosphataemia and he was treated as a hypokalaemic periodic paralysis patient. Intravenous potassium replacement was commenced. Symptoms and ECG changes resolved with correction of potassium levels. Thyroid function tests requested later were suggestive of hyperthyroidism and the diagnosis of thyrotoxic hypokalaemic periodic paralysis was made. This is an interesting case given its rarity, and this case report highlights the importance of early diagnosis and prompt treatment.

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A case report of sudden-onset upper and lower extremity weakness

Cited by 2 publications

References 6 publications

A Rare Case of Hypokalemic Periodic Paralysis With Acute Urinary Retention: Diagnosis and Management

A Rare Case of Hypokalemic Periodic Paralysis With Acute Urinary Retention: Diagnosis and Management

Thyrotoxic Periodic Paralysis: Case Presentation With Tetraparesis and Cardiac Dysrhythmia

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