A Case Report of the Treatment of Diabetic Foot Ulcers Using a Sodium Hyaluronate and Iodine Complex

Abstract

Diabetic foot ulcers are difficult to heal due to defects in local microvasculature and persistent, concomitant infection. Despite the best medical care, amputation is often a management option for this problem. The authors have developed a new and unique system for wound treatment, which is based on a combination of high molecular weight sodium hyaluronate with an iodine complex-Hyiodine (Contipro C, Dolní Dobrouc, Czech Republic). In this case report, the authors present an observational study on a series of patients with diabetic foot disease with nonhealing wounds treated with Hyiodine. The effect of the HA-iodine complex was studied on 18 patients suffering from complicated foot diabetic wounds. The HA-iodine complex was either spread directly over the wound, or more frequently, gauze was immersed in the HA-iodine complex and then put on/into the wound. Then several layers of dry gauze covered the wound. This dressing was changed every 24 hours. Wound healing was monitored daily, and wound pictures were taken each second week. Clinical improvement was observed in the majority. This suggests that the HA-iodine complex dressing has potential that needs to be developed from controlled studies.

The role of CD44 in cutaneous inflammation

“…In addition, increased accumulation of hyaluronic acid in the epidermis of CD44‐deficient mice could result in epidermal thickening. Accordingly, prior studies have shown that the accumulation of epidermal hyaluronic acid increases epidermal thickness following epidermal permeability barrier disruption (42), and topical application of low molecular weight hyaluronic acid fragment accelerates wound healing (58,59). Thus, a number of pathways could account for the increase in epidermal thickness in CD44‐deficient mice with chronic inflammation.…”

The role of hyaluronan in wound healing

“…However, the rate of complete healing was found to be similar in both groups at the secondary end point of 60 days. (37)(38)(39), yet none of these have been RCTs. Therefore, future research comparing to use a variety of HA-based dressings in RCTs may be of further clinical benefit.…”

Hyaluronan als Schlüssel zur schnelleren Wundheilung in humanen 3‑D-Vollhautmodellen

“…Darüber hinaus sind bereits Ansätze publiziert worden, in denen HA als Kombinationspräparat in der Therapie von problematischen, chronischen Wunden erfolgreich eingesetzt wurde. So konnten Sobotka et al [18] …”